Avolition domain of negative symptoms: electrophysiological correlates

König, Thomas; Giordano, Guilia Maria; Vignapiano, Annarita; Mucci, Armida (15 September 2017). Avolition domain of negative symptoms: electrophysiological correlates (Unpublished). In: 6th European Conference on Schizophrenia Research. Berlin. 14-16.Sept 2017.

Negative symptoms of schizophrenia constitute an important predictor for poor outcome, but remain a multi-factorial construct that requires additional neurobiological support. Thus, we tested whether different sub-dimensions of negative symptoms have specific brain functional correlates, as assessed by the distribution of subsecond global functional brain states (microstates).
EEG microstate features (duration, frequency of occurrence and time covered) of 142 schizophrenia patients were correlated with the negative symptom domains of avolition and expressive deficits.
The time spend in and occurrence of a particular microstate class (class A) was positively associated with avolition, but not expressive deficits, Further analyses limited this association to anticipatory anhedonia, apathy and asociality. In addition, asociality was negatively associated with time spent in microstate class D.
Our results indicate that negative symptoms is a biologically heterogeneous construct that needs to be further subdivided to identify the underlying dysfunctional brain systems.

Item Type:

Conference or Workshop Item (Speech)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

König, Thomas


500 Science
500 Science > 570 Life sciences; biology




Thomas König

Date Deposited:

29 Dec 2017 13:55

Last Modified:

05 Dec 2022 15:08



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