Insect Bite Hypersensitivity in Horses is Associated with Airway Hyperreactivity.

Lanz, Simone; Brunner, A; Graubner, Claudia; Marti, Eliane Isabelle; Gerber, Vinzenz (2017). Insect Bite Hypersensitivity in Horses is Associated with Airway Hyperreactivity. Journal of veterinary internal medicine, 31(6), pp. 1877-1883. Wiley-Blackwell 10.1111/jvim.14817

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BACKGROUND Genetic and epidemiologic evidence suggests that in horses, as in other species, different manifestations of hypersensitivity may occur together. HYPOTHESIS Horses affected with insect bite hypersensitivity (IBH) show airway hyperreactivity (AH) to inhaled histamine, even in the absence of overt clinical signs of equine asthma (EA). ANIMALS Twenty-two healthy controls (group C), 24 horses suffering from IBH alone (group IBH), and 23 horses suffering from IBH and EA (group IBH/EA). METHODS The clinical histories were assessed using 2 standardized questionnaires, the Horse Owner Assessed Respiratory Signs Index (HOARSI), and IBH scoring. Horses were classified as EA-affected if their HOARSI was >1 and as IBH-affected if IBH score was >0. Confounding disorders were excluded by clinical examination. The arterial partial pressure of oxygen (PaO2 ) was measured and flowmetric plethysmography used to assess airway reactivity to increasing doses of inhaled histamine. RESULTS The median histamine provocation concentration (PC) when ∆flow values increased by 35% (PC35) was significantly higher in group C (5.94 [1.11-26.33] mg/mL) compared to group IBH (2.95 [0.23-10.13] mg/mL) and group IBH/EA (2.03 [0.43-10.94] mg/mL; P < 0.01). The PC50 and PC75 showed very similar differences between groups. Furthermore, PaO2 was significantly lower in group IBH (84 ± 8 mmHg) and group IBH/EA (78 ± 11 mmHg) compared to group C (89 ± 6 mmHg; P < 0.01). CONCLUSIONS AND CLINICAL IMPORTANCE IBH is associated with AH and decreased PaO2 , even in the absence of overt respiratory clinical signs.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Lanz, Simone; Graubner, Claudia; Marti, Eliane Isabelle and Gerber, Vinzenz

Subjects:

600 Technology > 630 Agriculture

ISSN:

0891-6640

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Andrea Gassmann-Suter

Date Deposited:

02 May 2018 12:29

Last Modified:

02 May 2018 12:29

Publisher DOI:

10.1111/jvim.14817

PubMed ID:

28921663

Uncontrolled Keywords:

Equine asthma Horse Insect bite hypersensitivity Multiple equine allergies

BORIS DOI:

10.7892/boris.108386

URI:

https://boris.unibe.ch/id/eprint/108386

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