Does Integrated Neurocognitive Therapy (INT) reduce severe negative symptoms in schizophrenia outpatients?

Müller, Daniel; Khalesi, Zahra; Benzing, Valentin; Castiglione, Clelia I.; Roder, Volker (2017). Does Integrated Neurocognitive Therapy (INT) reduce severe negative symptoms in schizophrenia outpatients? Schizophrenia Research, 188, pp. 92-97. Elsevier 10.1016/j.schres.2017.01.037

[img] Text
Mueller.et.al_SchizophrRes.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (563kB) | Request a copy

Negative symptoms often inhibit the social integration of people suffering from schizophrenia. Reducing severe negative symptoms (SNS) in a clinically relevant way is a major unmet need. The aim of this study was to inves- tigate whether Integrated Neurocognitive Therapy (INT), a group cognitive remediation therapy (CRT), reduces SNS in schizophrenia outpatients. INT was compared with Treatment As Usual (TAU) in a randomized-controlled trial (RCT). A total of 61 SNS outpatients participated in the study, 28 were allocated to the INT group and 33 to the TAU group. A test-battery was used at baseline, post-treatment at 15 weeks, and 1-year-follow-up. Remission rates of SNS after therapy were significantly higher for INT compared to TAU. A trend favoring INT was obtained at follow-up. Furthermore, INT showed significantly higher functional outcome during follow-up compared to TAU. Regarding cognition, the strongest significant effect was found in attention post-treatment. No effects be- tween groups on more complex neurocognition and social cognition were evident. SNS outpatients seem to ac- cept INT group intervention as suggested by the high attendance rate.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
07 Faculty of Human Sciences > Institute of Sport Science (ISPW)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychotherapy
07 Faculty of Human Sciences > Institute of Sport Science (ISPW) > Sport Science I

UniBE Contributor:

Müller, Daniel; Benzing, Valentin Johannes and Roder, Volker

Subjects:

600 Technology > 610 Medicine & health
700 Arts > 790 Sports, games & entertainment

ISSN:

0920-9964

Publisher:

Elsevier

Language:

English

Submitter:

Daniel Müller

Date Deposited:

30 Jan 2018 13:48

Last Modified:

09 May 2018 11:24

Publisher DOI:

10.1016/j.schres.2017.01.037

PubMed ID:

28185784

Uncontrolled Keywords:

RCT Cognitive remediation, Group therapy, Integrated approach, negative symptoms

BORIS DOI:

10.7892/boris.108440

URI:

https://boris.unibe.ch/id/eprint/108440

Actions (login required)

Edit item Edit item
Provide Feedback