The Effects of Transcranial Stimulation on Language Related Large Scale Brain Networks

Kindler, Jochen; Hauf, Matinus; Hubl, Daniela (2017). The Effects of Transcranial Stimulation on Language Related Large Scale Brain Networks. Epileptologie, 34, pp. 31-37. Schweizerische Liga gegen Epilepsie

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The potential of brain stimulation techniques,
such as transcranial magnetic stimulation (TMS) and
transcranial direct current stimulation (tDCS), for therapeutic
purposes in neurologic and psychiatric diseases
is currently intensively investigated. The current article
provides a framework about the nature of long term effects
of TMS and tDCS, as seen after therapeutic brain
stimulation. Using auditory verbal hallucinations as
a specific example of language network computation
error, we demonstrate that brain stimulation changes
language network activity, simultaneously with clinical
improvements. Furthermore, we show that these
stimulation effects are propagated from the directly
stimulated region to structurally and functionally connected
remote areas. Thus, we conclude hypothesizing
that brain stimulation induces neuronal plasticity via
disrupting pathological network connectivity. This principle
of action needs to be further investigated in epilepsy:
as a diagnostic tool for the detection of essential
nods (hubs) within the epileptic large scale network in
the workup for disconnective surgergy and as a potential
therapeutical option for modifying non-invasively
the pathological activity within the epileptic network.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy

UniBE Contributor:

Kindler, Jochen, Hubl, Daniela

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1660-3656

Publisher:

Schweizerische Liga gegen Epilepsie

Language:

English

Submitter:

Daniela Hubl

Date Deposited:

29 Dec 2017 15:26

Last Modified:

05 Dec 2022 15:09

BORIS DOI:

10.7892/boris.108457

URI:

https://boris.unibe.ch/id/eprint/108457

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