Plasma Symmetric Dimethylarginine Concentration in Dogs with Acute Kidney Injury and Chronic Kidney Disease.

Dahlem, D P; Neiger, R; Schweighauser, Ariane; Francey, Thierry; Yerramilli, M; Obare, E; Steinbach, S M L (2017). Plasma Symmetric Dimethylarginine Concentration in Dogs with Acute Kidney Injury and Chronic Kidney Disease. Journal of veterinary internal medicine, 31(3), pp. 799-804. Wiley-Blackwell 10.1111/jvim.14694

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BACKGROUND Symmetric dimethylarginine (SDMA) is considered a biomarker for early detection of renal dysfunction in human patients with acute kidney injury (AKI). At present, no studies exist analyzing the relevance of SDMA in dogs with AKI. HYPOTHESIS/OBJECTIVES SDMA would correctly identify dogs with renal disease but would not be able to differentiate between AKI and CKD. ANIMALS Eighteen healthy control dogs, 48 dogs with AKI, and 29 dogs with CKD. METHODS Prospective study. Dogs with kidney disease were categorized as having AKI or CKD according to the history, clinical signs, laboratory findings, and results of diagnostic imaging. Plasma SDMA concentration was measured by IDEXX Laboratories. SDMA/creatinine ratio was calculated in dogs with AKI or CKD. RESULTS Median SDMA concentrations were 8.5 μg/dL (6-12 μg/dL), 39.5 μg/dL (8->100 μg/dL), and 35 μg/dL (12->100 μg/dL), in healthy, AKI, and CKD, respectively. SDMA concentrations were significantly higher in dogs with AKI (P < .0001) or CKD (P < .0001) in comparison with healthy dogs. Median SDMA/creatinine ratio in dogs with AKI and CKD was 6.5 (1.7-20.9) and 10 (2.4-33.9) (P = .0004), respectively. Although there was overlap of the SDMA/creatinine ratio in dogs with AKI or CKD, it was significantly higher in dogs with CKD compared to dogs with AKI (P = .0004). CONCLUSIONS AND CLINICAL IMPORTANCE In this population, SDMA was suitable for identifying dogs affected by AKI or CKD, but could not differentiate between them.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Internal Medicine

UniBE Contributor:

Schweighauser, Ariane and Francey, Thierry

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

0891-6640

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Thierry Francey-Spicher

Date Deposited:

01 May 2018 10:10

Last Modified:

01 May 2018 10:10

Publisher DOI:

10.1111/jvim.14694

PubMed ID:

28370549

Uncontrolled Keywords:

Azotemia Methylated arginines Renal biomarker Renal function

BORIS DOI:

10.7892/boris.108547

URI:

https://boris.unibe.ch/id/eprint/108547

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