The biomarker-based diagnosis of Alzheimer's disease. 2—lessons from oncology

Boccardi, Marina; Gallo, Valentina; Yasui, Yutaka; Vineis, Paolo; Padovani, Alessandro; Mosimann, Urs Peter; Giannakopoulos, Panteleimon; Gold, Gabriel; Dubois, Bruno; Jack, Clifford R.; Winblad, Bengt; Frisoni, Giovanni B.; Albanese, Emiliano (2017). The biomarker-based diagnosis of Alzheimer's disease. 2—lessons from oncology. Neurobiology of aging, 52, pp. 141-152. Elsevier 10.1016/j.neurobiolaging.2017.01.021

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Biomarkers for the diagnosis of Alzheimer's disease (AD) are not yet validated for use in clinical settings. We aim to provide a methodological framework for their systematic validation, by reference to that developed for oncology biomarkers. As for this discipline, the steps for the systematic validation of AD biomarkers need to target analytical validity, clinical validity, and clinical utility. However, the premises are different from oncology: the nature of disease (neurodegeneration vs. cancer), the purpose (improve diagnosis in clinically affected vs. screening preclinical individuals), and the target population (mild cognitive impairment patients referring to memory clinics vs. general population) lead to important differences, influencing both the design of validation studies and the use of selected biomarkers. This framework is applied within a wider initiative to assess the current available evidence on the clinical validity of biomarkers for AD, for the final aim to identify gaps and research priorities, and to inform coordinated research efforts boosting AD biomarkers research.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation

UniBE Contributor:

Mosimann, Urs Peter

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0197-4580

Publisher:

Elsevier

Language:

English

Submitter:

Angela Amira Botros

Date Deposited:

06 Mar 2018 14:12

Last Modified:

06 Mar 2018 14:12

Publisher DOI:

10.1016/j.neurobiolaging.2017.01.021

PubMed ID:

28317645

BORIS DOI:

10.7892/boris.108559

URI:

https://boris.unibe.ch/id/eprint/108559

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