Detection of Local Recurrence with 3-Tesla MRI After Radical Prostatectomy: A Useful Method for Radiation Treatment Planning?

Buergy, Daniel; Sertdemir, Metin; Weidner, Anja; Shelan, Mohamed; Lohr, Frank; Wenz, Frederik; Schoenberg, Stefan O; Attenberger, Ulrike I (2018). Detection of Local Recurrence with 3-Tesla MRI After Radical Prostatectomy: A Useful Method for Radiation Treatment Planning? In Vivo, 32(1), pp. 125-131. International Institute of Anticancer Research (IIAR) 10.21873/invivo.11214

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BACKGROUND/AIM Salvage radiotherapy improves biochemical control in patients with recurrence of prostate cancer after prostatectomy. Radiotherapy target volumes of the prostatic fossa are based on empirical data and differ between different guidelines. Localization of recurrence with multiparametric magnetic resonance imaging (MRI) might be a feasible approach to localize recurrent lesions. PATIENTS AND METHODS Twenty-one patients with biochemical recurrence after radical prostatectomy were included (median prostate-specific antigen (PSA) =0.17 ng/ml). Multi-parametric MRI was performed using a 3-T MR system. RESULTS Lesions were detected in seven patients with a median PSA of 0.86 ng/ml (minimum= 0.31 ng/ml). Patients without detectable recurrence had a median PSA of 0.12 ng/ml. All patients with detectable lesions responded to radiotherapy. Eleven out of 14 patients without detectable recurrence also responded. Plasma flow in suspicious lesions was correlated with PSA level. CONCLUSION Detection of recurrence at the prostatic fossa with our approach was possible in a minority of patients with a low PSA level. Clinical relevance of plasma flow in suspicious lesions should be further investigated.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Shelan, Mohamed

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0258-851X

Publisher:

International Institute of Anticancer Research (IIAR)

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

06 Apr 2018 09:56

Last Modified:

23 Oct 2019 17:31

Publisher DOI:

10.21873/invivo.11214

PubMed ID:

29275309

Uncontrolled Keywords:

MRI Prostate carcinoma radiation therapy radical prostatectomy salvage treatment

BORIS DOI:

10.7892/boris.108587

URI:

https://boris.unibe.ch/id/eprint/108587

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