Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study.

Canivell, S; Mohaupt, M; Ackermann, Daniel; Pruijm, M; Guessous, I; Ehret, G; Escher, G; Pechère-Bertschi, A; Vogt, B; Devuyst, O; Burnier, M; Martin, P-Y; Ponte, B; Bochud, M (2018). Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study. Journal of endocrinological investigation, 41(7), pp. 799-808. Kurtis 10.1007/s40618-017-0807-7

[img] Text
Canivelli JEndocrinolInvest 2017.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (531kB) | Request a copy

PURPOSE Arginine vasopressin (AVP) may be involved in metabolic syndrome (MetS) by altering liver glycogenolysis, insulin and glucagon secretion, and pituitary ACTH release. Moreover, AVP stimulates the expression of 11β-hydroxysteroid-dehydrogenase-type 2 (11β-HSD2) in mineralocorticosteroid cells. We explored whether apparent 11β-HSD2 activity, estimated using urinary cortisol-to-cortisone ratio, modulates the association between plasma copeptin, as AVP surrogate, and insulin resistance/MetS in the general adult population. METHODS This was a multicentric, family-based, cross-sectional sample of 1089 subjects, aged 18-90 years, 47% men, 13.4% MetS, in Switzerland. Mixed multivariable linear and logistic regression models were built to investigate the association of insulin resistance (HOMA-IR)/fasting glucose and MetS/Type 2 Diabetes with copeptin, while considering potential confounders or effect modifiers into account. Stratified results by age and 11β-HSD2 activity were presented as appropriate. RESULTS Plasma copeptin was higher in men [median 5.2, IQR (3.7-7.8) pmol/L] than in women [median 3.0, IQR (2.2-4.3) pmol/L], P < 0.0001. HOMA-IR was positively associated with copeptin after full adjustment if 11β-HSD2 activity was high [β (95% CI) = 0.32 (0.17-0.46), P < 0.001] or if age was high [β (95% CI) = 0.34 (0.20-0.48), P < 0.001], but not if either 11β-HSD2 activity or age was low. There was a positive association of type 2 diabetes with copeptin [OR (95% CI) = 2.07 (1.10-3.89), P = 0.024), but not for MetS (OR (95% CI) = 1.12 (0.74-1.69), P = 0.605), after full adjustment. CONCLUSIONS Our data suggest that age and apparent 11β-HSD2 activity modulate the association of copeptin with insulin resistance at the population level but not MeTS or diabetes. Further research is needed to corroborate these results and to understand the mechanisms underlying these findings.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Mohaupt, Markus and Ackermann, Daniel

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0391-4097

Publisher:

Kurtis

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

09 Jan 2018 17:03

Last Modified:

19 Jun 2018 01:30

Publisher DOI:

10.1007/s40618-017-0807-7

PubMed ID:

29235050

Uncontrolled Keywords:

11-β hydroxysteroid dehydrogenase type 2 enzyme Aging Copeptin Insulin resistance Interaction

BORIS DOI:

10.7892/boris.108663

URI:

https://boris.unibe.ch/id/eprint/108663

Actions (login required)

Edit item Edit item
Provide Feedback