Recent progress with next-generation biomarkers in muscle-invasive bladder cancer.

Contreras-Sanz, Alberto; Roberts, Morgan E; Seiler, Roland; Black, Peter C (2017). Recent progress with next-generation biomarkers in muscle-invasive bladder cancer. International journal of urology, 24(1), pp. 7-15. Wiley 10.1111/iju.13193

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Muscle-invasive bladder cancer is a heterogeneous disease with different clinical phenotypes. Histomorphological variants, variable mutation rates and aberrant protein expression, along with the recently identified molecular subtypes, have been linked to prognosis and response to therapy. Complete response to chemotherapy and outcome after radical cystectomy are difficult to predict. To date, no validated pathological or clinical test exists to predict response. Advances in high-throughput, next-generation, genomic techniques to study the molecular pathways that govern the disease have led to novel strategies for the identification of such biomarkers relevant to muscle-invasive bladder cancer. Progress has been made not only in tissue-based biomarkers, but also in the liquid biopsy field. Liquid biopsies represent an opportunity to obtain patient samples non-invasively at multiple time-points during their treatment course without the need for biopsy. Especially in the metastatic setting, this will allow monitoring of the molecular evolution of the tumor under treatment, which should inform subsequent therapeutic decisions.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Seiler-Blarer, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1442-2042

Publisher:

Wiley

Language:

English

Submitter:

Laetitia Hayoz

Date Deposited:

09 Jul 2018 10:36

Last Modified:

02 Mar 2023 23:30

Publisher DOI:

10.1111/iju.13193

PubMed ID:

27597124

Uncontrolled Keywords:

biomarker bladder cancer precision oncology recurrence targeted therapy

BORIS DOI:

10.7892/boris.108740

URI:

https://boris.unibe.ch/id/eprint/108740

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