Low Self-rated Health Is Related to Blood Hypercoagulability in Patients Admitted with Acute Myocardial Infarction

von Känel, Roland; Meister-Langraf, Rebecca E.; Schmid, Jean-Paul; Barth, Jürgen; Znoj, Hansjörg; Schnyder, Ulrich; Princip, Mary (2018). Low Self-rated Health Is Related to Blood Hypercoagulability in Patients Admitted with Acute Myocardial Infarction. Thrombosis and haemostasis, 118(1), pp. 54-62. Schattauer 10.1160/TH16-12-0964

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Self-rated health (SRH) is independently associated with all-cause mortality and adverse cardiovascular outcomes in individuals with and without cardiovascular disease. We examined whether SRH relates to haemostatic factors of a hypercoagulable state with prognostic impact in patients admitted with acute myocardial infarction (MI). We assessed 190 patients (median age: 59 years; all Caucasian; 83% men) within 48 hours of an acute coronary intervention in terms of demographic factors, medical and psychiatric comorbidity, health behaviours, cardiac-related variables and psychosocial characteristics. Patients rated their health state before MI retrospectively with the EuroQol Visual Analogue Scale ranging from 0 ('worst imaginable health state') to 100 ('best imaginable health state'). Circulating levels of fibrinogen, fibrin D-dimer and von Willebrand factor (VWF) antigen were measured the morning after hospital referral. The median score of SRH was 75 (range: 20-100). SRH was inversely associated with fibrinogen (r =  - 0.25, p = 0.001) and D-dimer (r =  - 0.17, p = 0.021) levels in the bivariate analysis. Stronger relationships emerged for fibrinogen (r =  - 0.33, p < 0.001), D-dimer (r =  - 0.25, p = 0.001) and also VWF (r =  - 0.19, p = 0.015) levels in fully adjusted linear regression models. As for SRH, the Global Registry of Acute Coronary Events (GRACE) risk score was the only covariate showing an independent association with all haemostatic factors (fibrinogen: r = 0.31, D-dimer: r = 0.29, VWF: r = 0.30; all p-values < 0.001). Lower SRH was associated with greater coagulability in patients with acute MI, independent of covariates and comparable with the GRACE risk score. The findings provide a novel psychobiological mechanism that may potentially link SRH with cardiovascular outcome in patients with an acute coronary syndrome.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy
07 Faculty of Human Sciences > Institute of Psychology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Psychosomatik

UniBE Contributor:

von Känel, Roland; Meister, Rebecca Elisabeth; Schmid-Walker, Jean-Paul; Znoj, Hans Jörg and Princip, Mary

Subjects:

600 Technology > 610 Medicine & health
100 Philosophy > 150 Psychology

ISSN:

0340-6245

Publisher:

Schattauer

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

16 Apr 2018 15:51

Last Modified:

05 Nov 2019 03:27

Publisher DOI:

10.1160/TH16-12-0964

PubMed ID:

29304525

BORIS DOI:

10.7892/boris.108818

URI:

https://boris.unibe.ch/id/eprint/108818

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