Differences in Epidural Pathology between Cervical and Thoracolumbar Intervertebral Disk Extrusions in Dogs.

Züger, Laura; Fadda, Angela; Oevermann, Anna; Forterre, Franck; Vandevelde, Marc; Henke, D (2018). Differences in Epidural Pathology between Cervical and Thoracolumbar Intervertebral Disk Extrusions in Dogs. Journal of veterinary internal medicine, 32(1), pp. 305-313. Wiley-Blackwell 10.1111/jvim.14887

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BACKGROUND Although the basic pathophysiology is the same in both cervical and thoracolumbar intervertebral disk (IVD) extrusions, there are considerable clinical differences that have only been partially explained. HYPOTHESIS/OBJECTIVES The epidural inflammatory response differs between cervical and thoracolumbar IVD extrusions. ANIMALS Fifty-five dogs with cervical and 80 dogs with thoracolumbar IVD extrusions. METHODS Clinical data and histopathologic variables were investigated. Associations between severity of epidural inflammation and clinical and pathologic variables, impact of chondrodystrophic phenotype, and localization (cervical versus thoracolumbar) were evaluated statistically. RESULTS Dogs with cervical IVD extrusion were significantly older (P < 0.001), had less severe and longer duration of neurologic signs (both P < 0.001), were more painful (P = 0.038), and had a better outcome (P = 0.005) than dogs with a thoracolumbar IVD extrusion. On histopathology, cervical epidural material had less severe calcification (P = 0.002) and inflammation (P < 0.001). No significant differences regarding chondrodystrophic phenotype were found. CONCLUSION AND CLINICAL IMPORTANCE There was significantly less intensive inflammatory response in the cervical epidural space. This observation correlated positively with less nucleus pulposus calcification in cervical extrusions indicating biochemical, metabolic, and biomechanical differences between the 2 locations, which remain to be characterized in future studies.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > NeuroCenter
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Surgery
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Züger, Laura; Fadda, Angela; Oevermann, Anna; Forterre, Franck and Vandevelde, Marc

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

0891-6640

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Simone Forterre

Date Deposited:

12 Apr 2018 12:23

Last Modified:

26 Oct 2019 23:26

Publisher DOI:

10.1111/jvim.14887

PubMed ID:

29194770

Uncontrolled Keywords:

IVD extrusion calcification cervical pain epidural inflammation

BORIS DOI:

10.7892/boris.108833

URI:

https://boris.unibe.ch/id/eprint/108833

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