Peripheral artery disease, redox signaling, oxidative stress - Basic and clinical aspects.

Steven, Sebastian; Daiber, Andreas; Dopheide, Jörn Fredrik; Münzel, Thomas; Espinola-Klein, Christine (2017). Peripheral artery disease, redox signaling, oxidative stress - Basic and clinical aspects. Redox biology, 12, pp. 787-797. Elsevier 10.1016/j.redox.2017.04.017

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Reactive oxygen and nitrogen species (ROS and RNS, e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. At higher concentrations, ROS and RNS lead to oxidative stress and oxidative damage of biomolecules (e.g. via formation of peroxynitrite, fenton chemistry). Peripheral artery disease (PAD) is characterized by severe ischemic conditions in the periphery leading to intermittent claudication and critical limb ischemia (end stage). It is well known that redox biology and oxidative stress play an important role in this setting. We here discuss the major pathways of oxidative stress and redox signaling underlying the disease progression with special emphasis on the contribution of inflammatory processes. We also highlight therapeutic strategies comprising pharmacological (e.g. statins, angiotensin-converting enzyme inhibitors, phosphodiesterase inhibition) and non-pharmacological (e.g. exercise) interventions. Both of these strategies induce potent indirect antioxidant and anti-inflammatory mechanisms that may contribute to an improvement of PAD associated complications and disease progression by removing excess formation of ROS and RNS (e.g. by ameliorating primary complications such as hyperlipidemia and hypertension) as well as the normalization of the inflammatory phenotype suppressing the progression of atherosclerosis.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Dopheide, Jörn Fredrik

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2213-2317

Publisher:

Elsevier

Language:

English

Submitter:

Catherine Gut

Date Deposited:

05 Mar 2018 08:46

Last Modified:

26 Oct 2019 03:40

Publisher DOI:

10.1016/j.redox.2017.04.017

PubMed ID:

28437655

Uncontrolled Keywords:

Antioxidant therapy Claudication and critical limb ischemia Oxidative stress Peripheral artery (occlusive) disease Redox signaling Walking distance

BORIS DOI:

10.7892/boris.108856

URI:

https://boris.unibe.ch/id/eprint/108856

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