Supervised exercise training in peripheral arterial disease increases vascular shear stress and profunda femoral artery diameter.

Dopheide, Jörn Fredrik; Rubrech, Jennifer; Trumpp, Amelie; Geissler, Philipp; Zeller, Geraldine C; Schnorbus, Boris; Schmidt, Frank; Gori, Tommaso; Münzel, Thomas; Espinola-Klein, Christine (2017). Supervised exercise training in peripheral arterial disease increases vascular shear stress and profunda femoral artery diameter. European journal of preventive cardiology, 24(2), pp. 178-191. SAGE Publications 10.1177/2047487316665231

[img] Text
2047487316665231.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

Background Arteriogenesis is promoted by flow- and pressure-related forces such as tangential wall stress and laminar shear stress. Exercise training (ET) is known to promote arteriogenesis in peripheral arterial disease (PAD) patients. It remains unclear whether supervised ET (SET) promotes arteriogenesis more efficiently than non-SET (nSET). Methods and results Forty PAD patients participated in a SET or nSET training programme ( n = 20 each) and were compared to 20 healthy individuals without any history of cardiovascular events. Femoral artery diameter, flow and velocity were measured by ultrasound. Tangential wall stress and laminar shear stress were calculated for femoral arteries. Follow-up was performed after a mean of 7.65 ± 1.62 months. At follow-up, only the SET group showed a significant increase in lumen diameter of the profunda femoral artery ( p = 0.03), accompanied by an increase of tangential wall stress ( p = 0.002). Laminar shear stress decreased, but remained higher for the SET group compared to controls ( p < 0.01). Individual changes in walking distance were higher for SET patients ( p = 0.01) than nSET patients ( p = 0.07). Profunda femoral lumen diameter and tangential wall stress correlated directly with walking distance ( r = 0.446; p < 0.001), as well as with each other ( r = 0.743; p < 0.0001). Conclusions Our results indicate that SET promotes arteriogenesis more efficiently than nSET. Femoral lumen diameter and flow might help with the monitoring of ET efficiency and potential arteriogenesis.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Dopheide, Jörn Fredrik


600 Technology > 610 Medicine & health




SAGE Publications




Catherine Gut

Date Deposited:

21 Feb 2018 12:32

Last Modified:

05 Dec 2022 15:09

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Peripheral arterial disease arteriogenesis exercise training laminar shear stress profunda femoral arterial diameter tangential wall stress




Actions (login required)

Edit item Edit item
Provide Feedback