Outcome predictors of radical cystectomy in patients with cT4 prostate cancer: a multi-institutional study of 62 patients.

Spahn, Martin; Morlacco, Alessandro; Boxler, Silvan; Joniau, Steven; Briganti, Alberto; Montorsi, Francesco; Gontero, Paolo; Bader, Pia; Frohneberg, Detlef; van Poppel, Hein; Karnes, Robert Jeffrey (2017). Outcome predictors of radical cystectomy in patients with cT4 prostate cancer: a multi-institutional study of 62 patients. BJU international, 120(5B), E52-E58. Blackwell Science 10.1111/bju.13818

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OBJECTIVES To identify which patients with macroscopic bladder-infiltrating T4 prostate cancer (PCa) might have favourable outcomes when treated with radical cystectomy (RC). MATERIALS AND METHODS We evaluated 62 patients with cT4cN0-1 cM0 PCa treated with RC and pelvic lymph node dissection between 1972 and 2011. In addition to descriptive statistics, the Kaplan-Meier method and log-rank tests were used to depict survival rates. Univariate and multivariate Cox regression analysis tested the association between predictors and progression-free, PCa-specific and overall survival. RESULTS Of the 62 patients, 19 (30.6%) did not have clinical progression during follow-up, two (3.2%) had local recurrence, and 32 (51.6%) had haematogenous and nine (14.5%) combined pelvic and distant metastasis. Forty patients (64.5%) died, 34 (54.8%) from PCa and six (9.7%) from other causes. The median (range) survival time of the 19 patients who were metastasis-free at last follow-up was 86 (1-314) months, 8/19 patients had a follow-up of >5 years, and five patients survived metastasis-free for >15 years. Patients without seminal vesicle invasion (SVI) had the best outcomes, with an estimated 10-year PCa-specific survival of 75% compared with 24% for patients with SVI. CONCLUSION For cT4 PCa RC can be an appropriate treatment for local control and part of a multimodality-treatment approach. Although recurrences are probable, these do not necessarily translate into cancer-specific death. Men without SVI had a 75% 10-year PCa-specific survival. Although outcomes for patients with SVI are not as favourable, there can be good local control; however, these patients are at higher risk of progression and may need more aggressive systemic treatment.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Spahn, Martin and Boxler, Silvan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1464-4096

Publisher:

Blackwell Science

Language:

English

Submitter:

Laetitia Hayoz

Date Deposited:

19 Feb 2018 11:42

Last Modified:

19 Feb 2018 11:42

Publisher DOI:

10.1111/bju.13818

PubMed ID:

28220605

Uncontrolled Keywords:

#PCSM #ProstateCancer #uroonc cystectomy high-risk prostate cancer locally advanced prostate cancer multimodality treatment surgery

BORIS DOI:

10.7892/boris.108865

URI:

https://boris.unibe.ch/id/eprint/108865

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