Preserved immunogenicity of an inactivated vaccine based on foot-and-mouth disease virus particles with improved stability

Caridi, Flavia; Vázquez-Calvo, Ángela; Borrego, Belén; McCullough, Kenneth; Summerfield, Artur; Sobrino, Francisco; Martín-Acebes, Miguel A. (2017). Preserved immunogenicity of an inactivated vaccine based on foot-and-mouth disease virus particles with improved stability. Veterinary microbiology, 203, pp. 275-279. Elsevier 10.1016/j.vetmic.2017.03.031

[img] Text
1-s2.0-S0378113517302304-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (791kB) | Request a copy

Foot-and-mouth disease virus (FMDV) is the etiological agent of a highly contagious disease that affects important livestock species. Vaccines based on inactivated FMDV virions provide a useful tool for the control of this pathogen. However, long term storage at 4°C (the temperature for vaccine storage) or ruptures of the cold chain, provoke the dissociation of virions, reducing the immunogenicity of the vaccine. An FMDV mutant carrying amino acid replacements VP1 N17D and VP2 H145Y isolated previously rendered virions with increased resistance to dissociation at 4°C. We have evaluated the immunogenicity in swine (a natural FMDV host) of a chemically inactivated vaccine based on this mutant. The presence of these amino acid substitutions did not compromise the immunological potential, including its ability to elicit neutralizing antibodies. These results support the feasibility of this kind of mutants with increased capsid stability as suitable viruses for producing improved FMDV vaccines.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

McCullough, Kenneth and Summerfield, Artur

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

0378-1135

Publisher:

Elsevier

Language:

English

Submitter:

Artur Summerfield

Date Deposited:

02 May 2018 12:50

Last Modified:

04 Jul 2018 08:46

Publisher DOI:

10.1016/j.vetmic.2017.03.031

PubMed ID:

28619156

BORIS DOI:

10.7892/boris.108906

URI:

https://boris.unibe.ch/id/eprint/108906

Actions (login required)

Edit item Edit item
Provide Feedback