Regulation of inflammation in Japanese encephalitis

Lannes, Nils; Summerfield, Artur; Filgueira, Luis (2017). Regulation of inflammation in Japanese encephalitis. Journal of neuroinflammation, 14(1), p. 158. BioMed Central 10.1186/s12974-017-0931-5

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BACKGROUND: Uncontrolled inflammatory response of the central nervous system is a hallmark of severe Japanese encephalitis (JE). Although inflammation is necessary to mount an efficient immune response against virus infections, exacerbated inflammatory response is often detrimental. In this context, cells of the monocytic lineage appear to be important forces driving JE pathogenesis. MAIN BODY: Brain-infiltrating monocytes, macrophages and microglia play a major role in central nervous system (CNS) inflammation during JE. Moreover, the role of inflammatory monocytes in viral neuroinvasion during JE and mechanisms of cell entry into the CNS remains unclear. The identification of cellular and molecular actors in JE inflammatory responses may help to understand the mechanisms behind excessive inflammation and to develop therapeutics to treat JE patients. This review addresses the current knowledge about mechanisms of virus neuroinvasion, neuroinflammation and therapeutics critical for JE outcome. CONCLUSION: Understanding the regulation of inflammation in JE is challenging. Elucidation of the remaining open questions will help to the development of therapeutic approaches avoiding detrimental inflammatory responses in JE.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Summerfield, Artur

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

1742-2094

Publisher:

BioMed Central

Language:

English

Submitter:

Artur Summerfield

Date Deposited:

02 May 2018 10:20

Last Modified:

04 Jul 2018 08:46

Publisher DOI:

10.1186/s12974-017-0931-5

PubMed ID:

28807053

BORIS DOI:

10.7892/boris.108907

URI:

https://boris.unibe.ch/id/eprint/108907

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