Regulation of inflammation in Japanese encephalitis

Lannes, Nils; Summerfield, Artur; Filgueira, Luis (2017). Regulation of inflammation in Japanese encephalitis. Journal of neuroinflammation, 14(1), p. 158. BioMed Central 10.1186/s12974-017-0931-5

Preview

Text s12974-017-0931-5.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (773kB) | Preview

BACKGROUND:

Uncontrolled inflammatory response of the central nervous system is a hallmark of severe Japanese encephalitis (JE). Although inflammation is necessary to mount an efficient immune response against virus infections, exacerbated inflammatory response is often detrimental. In this context, cells of the monocytic lineage appear to be important forces driving JE pathogenesis.

MAIN BODY:

Brain-infiltrating monocytes, macrophages and microglia play a major role in central nervous system (CNS) inflammation during JE. Moreover, the role of inflammatory monocytes in viral neuroinvasion during JE and mechanisms of cell entry into the CNS remains unclear. The identification of cellular and molecular actors in JE inflammatory responses may help to understand the mechanisms behind excessive inflammation and to develop therapeutics to treat JE patients. This review addresses the current knowledge about mechanisms of virus neuroinvasion, neuroinflammation and therapeutics critical for JE outcome.

CONCLUSION:

Understanding the regulation of inflammation in JE is challenging. Elucidation of the remaining open questions will help to the development of therapeutic approaches avoiding detrimental inflammatory responses in JE.

Interest & Impact

Downloads

177 since deposited on 02 May 2018
28 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item