Tumor Heterogeneity in Lymphomas: A Different Breed.

Schürch, Christian; Federmann, Birgit; Quintanilla-Martinez, Leticia; Fend, Falko (2018). Tumor Heterogeneity in Lymphomas: A Different Breed. Pathobiology, 85(1-2), pp. 130-145. Karger 10.1159/000475530

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The facts that cancer represents tissues consisting of heterogeneous neoplastic, as well as reactive, cell populations and that cancers of the same histotype may show profound differences in clinical behavior have long been recognized. With the advent of new technologies and the demands of precision medicine, the investigation of tumor heterogeneity has gained much interest. An understanding of intertumoral heterogeneity in patients with the same disease entity is necessary to optimally guide personalized treatment. In addition, increasing evidence indicates that different tumor areas or primary tumors and metastases in an individual patient can show significant intratumoral heterogeneity on different levels. This phenomenon can be driven by genomic instability, epigenetic events, the tumor microenvironment, and stochastic variations in cellular function and antitumoral therapies. These mechanisms may lead to branched subclonal evolution from a common progenitor clone, resulting in spatial variation between different tumor sites, disease progression, and treatment resistance. This review addresses tumor heterogeneity in lymphomas from a pathologist's viewpoint. The relationship between morphologic, immunophenotypic, and genetic heterogeneity is exemplified in different lymphoma entities and reviewed in the context of high-grade transformation and transdifferentiation. In addition, factors driving heterogeneity, as well as clinical and therapeutic implications of lymphoma heterogeneity, will be discussed.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Schürch, Christian

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1015-2008

Publisher:

Karger

Language:

English

Submitter:

Ekkehard Hewer

Date Deposited:

13 Feb 2018 17:04

Last Modified:

23 Oct 2019 07:42

Publisher DOI:

10.1159/000475530

PubMed ID:

28719907

Uncontrolled Keywords:

B-cell non-Hodgkin lymphoma Chronic lymphocytic leukemia/small lymphocytic lymphoma Clonal evolution Diffuse large B-cell lymphoma Follicular lymphoma Intratumoral heterogeneity Lymphoma Lymphoplasmacytic lymphoma Mantle cell lymphoma Tumor heterogeneity

BORIS DOI:

10.7892/boris.108991

URI:

https://boris.unibe.ch/id/eprint/108991

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