Mesenchymal stem cell-derived factors: Immuno-modulatory effects and therapeutic potential.

Volarevic, Vladislav; Gazdic, Marina; Simovic Markovic, Bojana; Jovicic, Nemanja; Djonov, Valentin; Arsenijevic, Nebojsa (2017). Mesenchymal stem cell-derived factors: Immuno-modulatory effects and therapeutic potential. BioFactors, 43(5), pp. 633-644. Wiley 10.1002/biof.1374

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Stem cell-based therapy is considered to be a new hope in transplantation medicine. Among stem cells, mesenchymal stem cells (MSCs) are, due to their differentiation and immuno-modulatory characteristics, the most commonly used as therapeutic agents in the treatment of immune-mediated diseases. MSCs migrate to the site of inflammation and modulate immune response. The capacity of MSC to alter phenotype and function of immune cells are largely due to the production of soluble factors which expression varies depending on the pathologic condition to which MSCs are exposed. Under inflammatory conditions, MSCs-derived factors suppress both innate and adaptive immunity by attenuating maturation and capacity for antigen presentation of dendritic cells, by inducing polarization of macrophages towards alternative phenotype, by inhibiting activation and proliferation of T and B lymphocytes and by reducing cytotoxicity of NK and NKT cells. In this review, we emphasized current findings regarding immuno-modulatory effects of MSC-derived factors and emphasize their potential in the therapy of immune-mediated diseases. © 2017 BioFactors, 43(5):633-644, 2017.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Volarevic, Vladislav and Djonov, Valentin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0951-6433

Publisher:

Wiley

Language:

English

Submitter:

David Christian Haberthür

Date Deposited:

17 Jan 2018 17:29

Last Modified:

25 Oct 2019 08:24

Publisher DOI:

10.1002/biof.1374

PubMed ID:

28718997

Uncontrolled Keywords:

immune response immune-mediated diseases inflammation mesenchymal stem cells soluble factors

BORIS DOI:

10.7892/boris.108999

URI:

https://boris.unibe.ch/id/eprint/108999

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