Microbeam radiation therapy - grid therapy and beyond: a clinical perspective.

Schültke, Elisabeth; Balosso, Jacques; Breslin, Thomas; Cavaletti, Guido; Djonov, Valentin; Esteve, Francois; Grotzer, Michael; Hildebrandt, Guido; Valdman, Alexander; Laissue, Jean (2017). Microbeam radiation therapy - grid therapy and beyond: a clinical perspective. British journal of radiology, 90(1078), p. 20170073. British Institute of Radiology 10.1259/bjr.20170073

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Microbeam irradiation is spatially fractionated radiation on a micrometer scale. Microbeam irradiation with therapeutic intent has become known as microbeam radiation therapy (MRT). The basic concept of MRT was developed in the 1980s, but it has not yet been tested in any human clinical trial, even though there is now a large number of animal studies demonstrating its marked therapeutic potential with an exceptional normal tissue sparing effect. Furthermore, MRT is conceptually similar to macroscopic grid based radiation therapy which has been used in clinical practice for decades. In this review, the potential clinical applications of MRT are analysed for both malignant and non-malignant diseases.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Djonov, Valentin and Laissue, Jean

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0007-1285

Publisher:

British Institute of Radiology

Language:

English

Submitter:

David Christian Haberthür

Date Deposited:

17 Jan 2018 17:18

Last Modified:

30 Oct 2019 11:07

Publisher DOI:

10.1259/bjr.20170073

PubMed ID:

28749174

BORIS DOI:

10.7892/boris.109001

URI:

https://boris.unibe.ch/id/eprint/109001

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