Primary hyperparathyroidism: Dynamic postoperative metabolic changes.

Kaderli, Reto Martin; Riss, Philipp; Geroldinger, Angelika; Selberherr, Andreas; Scheuba, Christian; Niederle, Bruno (2018). Primary hyperparathyroidism: Dynamic postoperative metabolic changes. Clinical endocrinology, 88(1), pp. 129-138. Blackwell Scientific Publications 10.1111/cen.13476

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OBJECTIVE Little is known about the natural changes in parathyroid function after successful parathyroid surgery for primary hyperparathyroidism. The association of intact parathyroid hormone (iPTH) and calcium (Ca) with "temporary hypoparathyroidism" and "hungry bone syndrome" (HBS) was evaluated. DESIGN Potential risk factors for temporary hypoparathyroidism and HBS were evaluated by taking blood samples before surgery, intra-operatively, at postoperative day (POD) 1, at POD 5 to 7, in postoperative week (POW) 8 and in postoperative month (POM) 6. PATIENTS Of 425 patients, 43 (10.1%) had temporary hypoparathyroidism and 36 (8.5%) had HBS. MEASUREMENTS The discriminative ability of iPTH and Ca on POD 1 for temporary hypoparathyroidism and HBS. RESULTS Intact parathyroid hormone (IPTH) on POD 1 showed the highest discriminative ability for temporary hypoparathyroidism (C-index = 0.952), but not for HBS. IPTH was helpful in diagnosing HBS between POD 5 and 7 (C-index = 0.708). Extending the model by including Ca resulted in little improvement of the discriminative ability for temporary hypoparathyroidism (C-index = 0.964) and a decreased discriminative ability for HBS (C-index = 0.705). Normal parathyroid metabolism was documented in 139 (32.7%) patients on POD 1 and in 423 (99.5%) 6 months postoperatively, while 2 (0.5%) patients had persistent hyperparathyroidism, one diagnosed between POD 5 and 7 and another at POW 8. No patients suffered from permanent hypoparathyroidism. CONCLUSIONS The necessity for Ca and vitamin D3 substitution cannot be predicted with certainty before POD 5 to 7 without serial laboratory measurements. Based on the results, a routine 8-week course of Ca and vitamin D3 treatment seems reasonable and its necessity should be evaluated in a follow-up study.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Kaderli, Reto Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0300-0664

Publisher:

Blackwell Scientific Publications

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

06 Apr 2018 15:17

Last Modified:

06 Apr 2018 15:17

Publisher DOI:

10.1111/cen.13476

PubMed ID:

28906021

Uncontrolled Keywords:

Parathyroidectomy biochemical changes hungry bone primary hyperparathyroidism temporary hypoparathyroidism

BORIS DOI:

10.7892/boris.109054

URI:

https://boris.unibe.ch/id/eprint/109054

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