Moore, Kenneth Todd; Kröll, Dino (2017). Influences of Obesity and Bariatric Surgery on the Clinical and Pharmacologic Profile of Rivaroxaban. American journal of medicine, 130(9), pp. 1024-1032. Elsevier 10.1016/j.amjmed.2017.05.011
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Moore Kroll AJM E-pub Avail On-line 08JUNE2017.pdf - Accepted Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (1MB) | Preview |
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1-s2.0-S0002934317305892-main.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (1MB) | Preview |
The health implications of obesity are myriad and multifaceted. Physiologic changes associated with obesity can affect the absorption, distribution, metabolism, and excretion of administered drugs, thereby altering their pharmacologic profiles. In 2016, the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis published recommendations about the use of direct oral anticoagulants (DOACs) in obese patients. This guidance provides uniform recommendations for all DOACs, yet data suggest that individual agents may be affected to different degrees by obesity. Moreover, there are no recommendations currently available to guide DOAC use in bariatric surgery patients, in whom anatomic and physiologic changes to the digestive system can influence drug pharmacokinetics. Our review of the available literature indicates that the clinical profile of the DOAC rivaroxaban is not affected by high weight or bariatric surgery; hence, it does not appear that rivaroxaban dosing needs to be altered in these patient populations.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery |
UniBE Contributor: |
Kröll, Dino |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0002-9343 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Lilian Karin Smith-Wirth |
Date Deposited: |
05 Mar 2018 13:04 |
Last Modified: |
05 Dec 2022 15:09 |
Publisher DOI: |
10.1016/j.amjmed.2017.05.011 |
PubMed ID: |
28601546 |
Uncontrolled Keywords: |
Anticoagulants Bariatric surgery Obesity Rivaroxaban Thromboprophylaxis |
BORIS DOI: |
10.7892/boris.109073 |
URI: |
https://boris.unibe.ch/id/eprint/109073 |
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