Influences of Obesity and Bariatric Surgery on the Clinical and Pharmacologic Profile of Rivaroxaban.

Moore, Kenneth Todd; Kröll, Dino (2017). Influences of Obesity and Bariatric Surgery on the Clinical and Pharmacologic Profile of Rivaroxaban. American journal of medicine, 130(9), pp. 1024-1032. Elsevier 10.1016/j.amjmed.2017.05.011

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The health implications of obesity are myriad and multifaceted. Physiologic changes associated with obesity can affect the absorption, distribution, metabolism, and excretion of administered drugs, thereby altering their pharmacologic profiles. In 2016, the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis published recommendations about the use of direct oral anticoagulants (DOACs) in obese patients. This guidance provides uniform recommendations for all DOACs, yet data suggest that individual agents may be affected to different degrees by obesity. Moreover, there are no recommendations currently available to guide DOAC use in bariatric surgery patients, in whom anatomic and physiologic changes to the digestive system can influence drug pharmacokinetics. Our review of the available literature indicates that the clinical profile of the DOAC rivaroxaban is not affected by high weight or bariatric surgery; hence, it does not appear that rivaroxaban dosing needs to be altered in these patient populations.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Kröll, Dino

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0002-9343

Publisher:

Elsevier

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

05 Mar 2018 13:04

Last Modified:

23 Oct 2019 01:34

Publisher DOI:

10.1016/j.amjmed.2017.05.011

PubMed ID:

28601546

Uncontrolled Keywords:

Anticoagulants Bariatric surgery Obesity Rivaroxaban Thromboprophylaxis

BORIS DOI:

10.7892/boris.109073

URI:

https://boris.unibe.ch/id/eprint/109073

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