What is precision medicine?

König, Inke R; Fuchs, Oliver; Hansen, Gesine; von Mutius, Erika; Kopp, Matthias V (2017). What is precision medicine? European respiratory journal, 50(4) European Respiratory Society 10.1183/13993003.00391-2017

[img] Text
29051268.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (449kB) | Request a copy

The term "precision medicine" has become very popular over recent years, fuelled by scientific as well as political perspectives. Despite its popularity, its exact meaning, and how it is different from other popular terms such as "stratified medicine", "targeted therapy" or "deep phenotyping" remains unclear. Commonly applied definitions focus on the stratification of patients, sometimes referred to as a novel taxonomy, and this is derived using large-scale data including clinical, lifestyle, genetic and further biomarker information, thus going beyond the classical "signs-and-symptoms" approach.While these aspects are relevant, this description leaves open a number of questions. For example, when does precision medicine begin? In which way does the stratification of patients translate into better healthcare? And can precision medicine be viewed as the end-point of a novel stratification of patients, as implied, or is it rather a greater whole?To clarify this, the aim of this paper is to provide a more comprehensive definition that focuses on precision medicine as a process. It will be shown that this proposed framework incorporates the derivation of novel taxonomies and their role in healthcare as part of the cycle, but also covers related terms.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

UniBE Contributor:

Fuchs, Oliver

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0903-1936

Publisher:

European Respiratory Society

Language:

English

Submitter:

Romy Melanie Rodriguez Del Rio

Date Deposited:

12 Feb 2018 12:56

Last Modified:

12 Feb 2018 12:56

Publisher DOI:

10.1183/13993003.00391-2017

PubMed ID:

29051268

BORIS DOI:

10.7892/boris.109251

URI:

https://boris.unibe.ch/id/eprint/109251

Actions (login required)

Edit item Edit item
Provide Feedback