A simple method to reconstruct the molar mass signal of respiratory gas to assess small airways with a double-tracer gas single-breath washout.

Port, Johannes; Tao, Ziran; Junger, Annika; Joppek, Christoph; Tempel, Philipp; Husemann, Kim; Singer, Florian; Latzin, Philipp; Yammine, Sophie; Nagel, Joachim H; Kohlhäufl, Martin (2017). A simple method to reconstruct the molar mass signal of respiratory gas to assess small airways with a double-tracer gas single-breath washout. Medical & biological engineering & computing, 55(11), pp. 1975-1987. Springer 10.1007/s11517-017-1633-y

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For the assessment of small airway diseases, a noninvasive double-tracer gas single-breath washout (DTG-SBW) with sulfur hexafluoride (SF6) and helium (He) as tracer components has been proposed. It is assumed that small airway diseases may produce typical ventilation inhomogeneities which can be detected within one single tidal breath, when using two tracer components. Characteristic parameters calculated from a relative molar mass (MM) signal of the airflow during the washout expiration phase are analyzed. The DTG-SBW signal is acquired by subtracting a reconstructed MM signal without tracer gas from the signal measured with an ultrasonic sensor during in- and exhalation of the double-tracer gas for one tidal breath. In this paper, a simple method to determine the reconstructed MM signal is presented. Measurements on subjects with and without obstructive lung diseases including the small airways have shown high reliability and reproducibility of this method.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0140-0118

Publisher:

Springer

Language:

English

Submitter:

Romy Melanie Rodriguez Del Rio

Date Deposited:

26 Apr 2018 15:01

Last Modified:

24 Oct 2019 22:21

Publisher DOI:

10.1007/s11517-017-1633-y

PubMed ID:

28357624

Uncontrolled Keywords:

Double-tracer gas single-breath washout (DTG-SBW) OLS Signal reconstruction Small airway diseases

BORIS DOI:

10.7892/boris.109252

URI:

https://boris.unibe.ch/id/eprint/109252

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