Novel ultrasound-based methods to assess liver disease: The game has just begun.

Berzigotti, Annalisa; Ferraioli, Giovanna; Bota, Simona; Gilja, Odd Helge; Dietrich, Christoph F (2018). Novel ultrasound-based methods to assess liver disease: The game has just begun. Digestive and liver disease, 50(2), pp. 107-112. Elsevier 10.1016/j.dld.2017.11.019

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In the last 10 years the availability of ultrasound elastography allowed to diagnose and stage liver fibrosis in a non-invasive way and changed the clinical practice of hepatology. Newer ultrasound-based techniques to evaluate properties of the liver tissue other than fibrosis are emerging and will lead to a more complete characterization of the full spectrum of diffuse and focal liver disease. Since these methods are currently undergoing validation and go beyond elastography for liver tissue evaluation, they were not included in the recent guidelines regarding elastography issued by the European Federation of Societies in Ultrasound in Medicine and Biology. In this review paper, we outline the major advances in the field of ultrasound for liver applications, with special emphasis on techniques that could soon be part of the future armamentarium of ultrasound specialists devoted to the assessment of liver disease. Specifically, we discuss current and future ultrasound assessment of steatosis, spleen stiffness for portal hypertension, and elastography for the evaluation of focal liver lesions; we also provide a short glimpse into the next generation of ultrasound diagnostic methods.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Berzigotti, Annalisa


600 Technology > 610 Medicine & health








Thi Thao Anh Pham

Date Deposited:

30 Jan 2018 12:40

Last Modified:

05 Dec 2022 15:09

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Cirrhosis Fibrosis Focal lesions Guidelines Shear wave elastography




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