Contrast enhanced ultrasound in mixed hepatocellular cholangiocarcinoma: Case series and review of the literature.

Dong, Yi; Teufel, Andreas; Trojan, Jörg; Berzigotti, Annalisa; Cui, Xin Wu; Dietrich, Christoph F (2018). Contrast enhanced ultrasound in mixed hepatocellular cholangiocarcinoma: Case series and review of the literature. Digestive and liver disease, 50(4), pp. 401-407. Elsevier 10.1016/j.dld.2017.11.003

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BACKGROUND Mixed hepatocellular cholangiocarcinoma is a rare form of primary liver cancer. AIMS The aim of this study is to report the results of the use of contrast enhanced ultrasound in a series of patients with confirmed mixed hepatocellular cholangiocarcinoma and to provide an updated literature review. METHODS Between January 2012 and October 2016, 25 Asian patients with confirmed mixed hepatocellular cholangiocarcinoma were included in this bicentric retrospective analysis. Clinical data as well recorded images of a standardized conventional B-mode ultrasound and contrast-enhanced ultrasound examination were interpreted by two blinded, independent, experienced radiologists in consensus. RESULTS All mixed hepatocellular cholangiocarcinoma lesions were heteroechoic on B-mode ultrasound, with ill-defined margins and irregular shapes. Arterial phase hyperenhancement was present in all 25 patients. Late-phase washout and hypoenhancement was present in 24/25 (96%) patients. However, rim-enhancement and early wash-out (which are common in cholangiocellular carcinoma) were found in over 60% of the cases. CONCLUSION Contrast-enhanced ultrasound demonstrated findings not typical for HCC in a large proportion of patients with confirmed mixed hepatocellular cholangiocarcinoma. Therefore, histological confirmation is crucial, especially in lesions with atypical findings.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Berzigotti, Annalisa

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1590-8658

Publisher:

Elsevier

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

30 Jan 2018 15:54

Last Modified:

02 Apr 2018 01:31

Publisher DOI:

10.1016/j.dld.2017.11.003

PubMed ID:

29233685

Uncontrolled Keywords:

Contrast-enhanced ultrasound (CEUS) Diagnosis Differentiate Mixed hepatocellular cholangiocarcinoma (HCC–CCA);

BORIS DOI:

10.7892/boris.109574

URI:

https://boris.unibe.ch/id/eprint/109574

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