Behavioral depression is associated with increased vagally mediated heart rate variability in adult female cynomolgus monkeys (Macaca fascicularis)

Jarczok, Marc N.; Koenig, Julian; Shively, Carol A.; Thayer, Julian F. (2018). Behavioral depression is associated with increased vagally mediated heart rate variability in adult female cynomolgus monkeys (Macaca fascicularis). International journal of psychophysiology, 131, pp. 139-143. Elsevier 10.1016/j.ijpsycho.2017.11.004

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INTRODUCTION: Depressive symptoms (DS) in humans are associated with decreased resting state vagal activity, but sex seems to moderate this association. Recently, in human females DS have been associated with greater or similar cardiac vagal activity compared to men in both, clinical and non-clinical samples. A previously validated animal model of behavioral depression was used in the present study to investigate the association of DS and cardiac vagal activity in non-human primates. METHODS: The root mean square of successive differences between adjacent heart beats (RMSSD) was used as an indicator of vagally-mediated heart rate variability in 24h heart rate recordings collected via telemetry in 42 adult female cynomolgus monkeys (Macaca fascicularis). Hierarchical regression models were used to estimate differences in RMSSD comparing monkeys with and without DS. To capture circadian variation patterns of RMSSD, additional quadratic, cubic and quartic terms of hour were added. RESULTS: Monkeys showing behavioral DS had higher overall 24-h RMSSD. The interaction term of daytime with DS and polynomials of hour contributed significantly to the variance across models. CONCLUSIONS: This is the first study investigating the association of DS and 24h cardiac vagal control in female non-human primates. Results replicate existing human studies showing higher cardiac vagal control in behavioral depressed vs. non-depressed female monkeys.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division

UniBE Contributor:

Koenig, Julian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0167-8760

Publisher:

Elsevier

Language:

English

Submitter:

Livia Hug

Date Deposited:

28 Mar 2018 13:52

Last Modified:

24 Oct 2019 17:15

Publisher DOI:

10.1016/j.ijpsycho.2017.11.004

PubMed ID:

29128294

Uncontrolled Keywords:

Depression, Heart rate variability, animal model, depressive symptoms, non-human primate, sex difference

BORIS DOI:

10.7892/boris.109809

URI:

https://boris.unibe.ch/id/eprint/109809

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