Human brain patterns underlying vigilant attention: impact of sleep debt, circadian phase and attentional engagement.

Maire, M; Reichert, C F; Gabel, V; Viola, A U; Phillips, C; Berthomier, C; Borgwardt, S; Cajochen, C; Schmidt, C (2018). Human brain patterns underlying vigilant attention: impact of sleep debt, circadian phase and attentional engagement. Scientific Reports, 8(1), p. 970. Nature Publishing Group 10.1038/s41598-017-17022-9

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Sleepiness and cognitive function vary over the 24-h day due to circadian and sleep-wake-dependent mechanisms. However, the underlying cerebral hallmarks associated with these variations remain to be fully established. Using functional magnetic resonance imaging (fMRI), we investigated brain responses associated with circadian and homeostatic sleep-wake-driven dynamics of subjective sleepiness throughout day and night. Healthy volunteers regularly performed a psychomotor vigilance task (PVT) in the MR-scanner during a 40-h sleep deprivation (high sleep pressure) and a 40-h multiple nap protocol (low sleep pressure). When sleep deprived, arousal-promoting thalamic activation during optimal PVT performance paralleled the time course of subjective sleepiness with peaks at night and troughs on the subsequent day. Conversely, task-related cortical activation decreased when sleepiness increased as a consequence of higher sleep debt. Under low sleep pressure, we did not observe any significant temporal association between PVT-related brain activation and subjective sleepiness. Thus, a circadian modulation in brain correlates of vigilant attention was only detectable under high sleep pressure conditions. Our data indicate that circadian and sleep homeostatic processes impact on vigilant attention via specific mechanisms; mirrored in a decline of cortical resources under high sleep pressure, opposed by a subcortical "rescuing" at adverse circadian times.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)

UniBE Contributor:

Maire, Micheline

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2045-2322

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

23 Jan 2018 12:03

Last Modified:

23 Oct 2019 02:46

Publisher DOI:

10.1038/s41598-017-17022-9

PubMed ID:

29343686

BORIS DOI:

10.7892/boris.109936

URI:

https://boris.unibe.ch/id/eprint/109936

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