Early Detection of Subclinical Myocardial Damage in Chronic Aortic Regurgitation and Strategies for Timely Treatment of Asymptomatic Patients.

Lee, Joe K T; Franzone, Anna; Lanz, Jonas; Siontis, George C M; Stortecky, Stefan; Gräni, Christoph; Roost, Eva; Windecker, Stephan; Pilgrim, Thomas (2018). Early Detection of Subclinical Myocardial Damage in Chronic Aortic Regurgitation and Strategies for Timely Treatment of Asymptomatic Patients. Circulation, 137(2), pp. 184-196. Lippincott Williams & Wilkins 10.1161/CIRCULATIONAHA.117.029858

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A series of hemodynamic and pathological responses occur in chronic aortic regurgitation, which eventually result in myocardial fibrosis and irreversible left ventricular dysfunction. According to guidelines, valvular surgery is recommended with the development of symptoms, left ventricular systolic dysfunction, or left ventricular dilatation. The optimal timing of surgical intervention has recently been questioned with documentation of irreversible myocardial damage resulting in incomplete left ventricular recovery and adverse clinical outcomes after surgery. Recognizing the shortcomings of the guidelines, we performed a comprehensive review on the novel diagnostic methods that have been shown to improve the detection of subclinical ventricular dysfunction in chronic aortic regurgitation and to improve prediction of outcomes.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Franzone, Anna; Lanz, Jonas; Stortecky, Stefan; Gräni, Christoph; Roost, Eva; Windecker, Stephan and Pilgrim, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0009-7322

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Daniela Huber

Date Deposited:

15 Mar 2018 09:02

Last Modified:

15 Mar 2018 09:02

Publisher DOI:

10.1161/CIRCULATIONAHA.117.029858

PubMed ID:

29311349

Uncontrolled Keywords:

aortic valve insufficiency diagnostic imaging echocardiography magnetic resonance imaging natriuretic peptide, brain

BORIS DOI:

10.7892/boris.109982

URI:

https://boris.unibe.ch/id/eprint/109982

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