Menendez, Maria I; Hettlich, Bianca Felicitas; Wei, Lai; Knopp, Michael V (2017). Feasibility of Na18F PET/CT and MRI for Noninvasive In Vivo Quantification of Knee Pathophysiological Bone Metabolism in a Canine Model of Post-traumatic Osteoarthritis. Molecular imaging, 16, p. 1536012117714575. SAGE Publications 10.1177/1536012117714575
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PURPOSE
To assess and quantify by molecular imaging knee osseous metabolic changes serially in an in vivo canine model of posttraumatic osteoarthritis (PTOA) of the knee utilizing sodium fluoride (Na18F) positron emission tomography (PET)/computed tomography (CT) coregistered with magnetic resonance imaging (MRI).
MATERIALS AND METHODS
Sodium fluoride PET imaging of 5 canines was performed prior to anterior cruciate ligament transection (ACLT) and 2 times post-ACLT (3 and 12 weeks). The PET/CT was coregistered with MRI, enabling serial anatomically guided visual and quantitative three-dimensional (3D) region of interest (ROI) assessment by maximum standardized uptake value.
RESULTS
Prior to ACLT, every 3D ROI assessed in both knees showed no Na18F uptake above background. The uptake of Na18F in the bone of the ACLT knees increased exponentially, presenting significantly higher uptake at 12 weeks in every region compared to the ACLT knees at baseline. Furthermore, the uninjured contralateral limb and the ipsilateral distal bones and joints presented Na18F uptake at 3 and 12 weeks post-ACLT.
CONCLUSION
This study demonstrated that Na18F PET/CT coregistered with MRI is a feasible molecular imaging biomarker to assess knee osseous metabolic changes serially in an in vivo canine model of knee PTOA. Moreover, it brings a novel musculoskeletal preclinical imaging methodology that can provide unique insights into PTOA pathophysiology.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Surgery 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic |
UniBE Contributor: |
Hettlich, Bianca Felicitas |
Subjects: |
600 Technology > 630 Agriculture 600 Technology > 610 Medicine & health |
ISSN: |
1536-0121 |
Publisher: |
SAGE Publications |
Language: |
English |
Submitter: |
Bianca Felicitas Hettlich |
Date Deposited: |
02 May 2018 08:49 |
Last Modified: |
05 Dec 2022 15:09 |
Publisher DOI: |
10.1177/1536012117714575 |
PubMed ID: |
28730928 |
Uncontrolled Keywords: |
MRI Na-18fluoride PET/CT animal model bone remodeling knee osteoarthritis multimodality imaging post-traumatic osteoarthritis |
BORIS DOI: |
10.7892/boris.110015 |
URI: |
https://boris.unibe.ch/id/eprint/110015 |
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