The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning.

Olivares, Ana Maria; Han, Yinan; Soto, David; Flattery, Kyle; Marini, Joseph; Mollema, Nissa; Haider, Ali; Escher, Pascal; DeAngelis, Margaret M; Haider, Neena B (2017). The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning. Developmental biology, 429(1), pp. 343-355. Elsevier 10.1016/j.ydbio.2017.05.021

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Nuclear hormone receptors play a major role in the development of many tissues. This study uncovers a novel role for testicular receptor 2 (Tr2, Nr2c1) in defining the early phase of retinal development and regulating normal retinal cell patterning and topography. The mammalian retina undergoes an overlapping yet biphasic period of development to generate all seven retinal cell types. We discovered that Nr2c1 expression coincides with development of the early retinal cells. Loss of Nr2c1 causes a severe vision deficit and impacts early, but not late retina cell types. Retinal cone cell topography is disrupted with an increase in displaced amacrine cells. Additionally, genetic background significantly impacts phenotypic outcome of cone photoreceptor cells but not amacrine cells. Chromatin-IP experiments reveal NR2C1 regulates early cell transcription factors that regulate retinal progenitor cells during development, including amacrine (Satb2) and cone photoreceptor regulators thyroid and retinoic acid receptors. This study supports a role for Nr2c1 in defining the biphasic period of retinal development and specifically influencing the early phase of retinal cell fate.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Escher, Pascal

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0012-1606

Publisher:

Elsevier

Language:

English

Submitter:

Pascal Escher

Date Deposited:

01 Mar 2018 11:21

Last Modified:

18 Apr 2019 15:17

Publisher DOI:

10.1016/j.ydbio.2017.05.021

Related URLs:

PubMed ID:

28551284

Uncontrolled Keywords:

Cell proliferation Cone cell patterning Development Nuclear hormone receptors Retina

BORIS DOI:

10.7892/boris.110029

URI:

https://boris.unibe.ch/id/eprint/110029

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