The Spatial Distribution of Perseverations in Neglect Patients during a Nonverbal Fluency Task Depends on the Integrity of the Right Putamen.

Kaufmann, B C; Frey, J; Pflugshaupt, T; Wyss, Patric; Paladini, Rebecca Elise; Vanbellingen, Tim; Bohlhalter, S; Chechlacz, M; Nef, Tobias; Müri, René Martin; Cazzoli, Dario; Nyffeler, Thomas (2018). The Spatial Distribution of Perseverations in Neglect Patients during a Nonverbal Fluency Task Depends on the Integrity of the Right Putamen. Neuropsychologia, 115, pp. 42-50. Elsevier 10.1016/j.neuropsychologia.2018.01.025

[img] Text
1-s2.0-S0028393218300253-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (982kB) | Request a copy
[img] Text
11282017_Paper_Revised_Kaufmann2018_.pdf - Accepted Version
Restricted to registered users only until 2 January 2020.
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (1MB) | Request a copy

Deficient inhibitory control leading to perseverative behaviour is often observed in neglect patients. Previous studies investigating the relationship between response inhibition and visual attention have reported contradictory results: some studies found a linear relationship between neglect severity and perseverative behaviour whereas others could not replicate this result. The aim of the present study was to shed further light on the interplay between visual attention and response inhibition in neglect, and to investigate the neural underpinnings of this interplay. We propose the use of the Five-Point Test, a test commonly used to asses nonverbal fluency, as a novel approach in the context of neglect. In the Five-Point Test, participants are required to generate as many different designs as possible, by connecting dots within forty rectangles. We hypothesised that, because of its clear definition of perseverative errors, the Five-Point Test would accurately assess both visual attention as well as perseverative behaviour. We assessed 46 neglect patients with right-hemispheric stroke, and performed voxel-based lesion-symptom mapping (VLSM) to identify neural substrates of perseverative behaviour as well as the spatial distribution of perseverations. Our results showed that the Five-Point Test can reliably measure neglect and perseverative behaviour. We did not find any significant relationship between neglect severity and the frequency of perseverations. However, within the subgroup of neglect patients who displayed perseverative behaviour, the spatial distribution of perseverations significantly depended on the integrity of the right putamen. We discuss the putative role of the putamen as a potential subcortical hub to modulate the complex integration between visual attention and response inhibition processes.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Perzeption und Okulomotorik
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation

UniBE Contributor:

Wyss, Patric; Paladini, Rebecca Elise; Vanbellingen, Tim; Nef, Tobias; Müri, René Martin; Cazzoli, Dario and Nyffeler, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0028-3932

Publisher:

Elsevier

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

09 Apr 2018 16:29

Last Modified:

05 Nov 2019 00:59

Publisher DOI:

10.1016/j.neuropsychologia.2018.01.025

PubMed ID:

29360517

Uncontrolled Keywords:

Five-Point Test Lesion mapping Neglect Putamen Response Inhibition Visual Attention

BORIS DOI:

10.7892/boris.110042

URI:

https://boris.unibe.ch/id/eprint/110042

Actions (login required)

Edit item Edit item
Provide Feedback