Testicular Steroidogenesis

Flück Pandey, Christa Emma; Pandey, Amit Vikram (2017). Testicular Steroidogenesis. In: Simoni, Manuela; Huhtaniemi, Ilpo T (eds.) Endocrinology of the Testis and Male Reproduction. Endocrinology (pp. 1-29). Cham: Springer International Publishing 10.1007/978-3-319-29456-8_10-1

[img] Text
2017_Endo_Testis.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (992kB) | Request a copy

Testosterone is the major androgen in circulation in male humans, produced primarily in the Leydig cells of the testis. Biosynthesis of testosterone from cholesteroloccursviaaseriesofenzymaticreactions.Testosteronemaybefurther metabolized into a more potent androgen, dihydrotestosterone. In recent years an alternate pathway of dihydrotestosterone biosynthesis without using testosterone as a precursor has emerged. Majority of classically studied effects of androgens are thought to be mediated via nuclear receptor-dependent long-term transcriptional effects, but there also exist membrane receptor-based effects of androgens which are being uncovered from recent studies that may explain rapid effects of androgens in many cases. In this chapter we are describing the biosynthesis, mechanism of action, and therapeutic effects of testosterone and related androgens.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Endokrinologie / Diabetologie / Metabolik (Pädiatrie)

UniBE Contributor:

Flück Pandey, Christa Emma and Pandey, Amit Vikram

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISBN:

978-3-319-29456-8

Series:

Endocrinology

Publisher:

Springer International Publishing

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Amit Vikram Pandey

Date Deposited:

20 Feb 2018 09:21

Last Modified:

20 Feb 2018 09:21

Publisher DOI:

10.1007/978-3-319-29456-8_10-1

Related URLs:

Uncontrolled Keywords:

Androgens, Anabolic steroids, Androgen receptor, Testosterone, CYP17A1, SRD5A1, Dihydrotestosterone

BORIS DOI:

10.7892/boris.110069

URI:

https://boris.unibe.ch/id/eprint/110069

Actions (login required)

Edit item Edit item
Provide Feedback