Neural Correlates of Semantic Priming in Psychosis

Zengaffinen, Francilia Sabrina; Furger, Stephan Niklaus; Stahnke, Antje; Dierks, Thomas; Federspiel, Andrea; Hatzinger, Martin; König, Thomas; Nick, Beat; Rapp, Charlotte; Stegmayer, Katharina; Strik, Werner; Walther, Sebastian; Wiest, Roland; Papmeyer, Martina (1 September 2017). Neural Correlates of Semantic Priming in Psychosis (Unpublished). In: International Conference on Basic and Clinical Multimodal Imaging. Bern. 29.08-02.09.2017.

Psychoses are aetiologically complex disorders that affect about 1 − 2% of the population during their lifetime. Psychotic symptoms are thought to represent disturbances in higher-order brain functions that can be grouped according to their dysfunction in one or more of the following three neural brain circuitries: language, affect, motor function. Dysfunction of the neural language brain circuitry has already been linked to disturbances in expressive speech and formal thought disorders. However, it remains currently unknown if the language brain circuitry is only disturbed in psychosis, or if already individuals at familial or clinical high-risk show some extend of aberrancy. To examine the whole spectrum form health to psychosis, four different subject groups are being examined: healthy controls (HC), first-degree relatives of psychosis patients (REL), a clinical high-risk group (CHR) and psychosis patients (PAT). In total, 120 subjects (30 per group) will complete a lexical priming task during electroencephalography and functional magnetic resonance imaging. On a behavioural level, we expect to find subtle language dysfunction in the REL and CHR group. Furthermore, we hypothesize that aberrant neural activation patterns are present during the language task in PAT, CHR and REL groups in comparison to HC individuals. Finally, we aim to depict that aberrant neural activation in language - related brain areas is most pronounced in the PAT group and to a lesser extend present in the REL group. With this study, we hope to improve diagnostic strategies, treatments and outcome predictions.

Item Type:

Conference or Workshop Item (Poster)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Zengaffinen, Francilia Sabrina; Furger, Stephan Niklaus; Stahnke, Antje; Dierks, Thomas; Federspiel, Andrea; König, Thomas; Stegmayer, Katharina; Strik, Werner; Walther, Sebastian; Wiest, Roland and Papmeyer, Martina

Subjects:

600 Technology > 610 Medicine & health

Projects:

[882] Symptom Dimensions of Psychopathology: From Health to Psychosis – The Dimensions of Language, Affect and Motor Function Official URL

Language:

English

Submitter:

Francilia Sabrina Zengaffinen

Date Deposited:

25 Jan 2018 11:44

Last Modified:

25 Jan 2018 11:44

Uncontrolled Keywords:

SYNOPSIS

URI:

https://boris.unibe.ch/id/eprint/110143

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