Nail psoriasis: clinical features, pathogenesis, differential diagnoses, and management

Haneke, Eckart (2017). Nail psoriasis: clinical features, pathogenesis, differential diagnoses, and management. Psoriasis - targets and therapy, 7, pp. 51-63. Dove Medical Press 10.2147/PTT.S126281

[img]
Preview
Text
PTT-126281-nail-psoriasis--impact-and-management-challenges_101617.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC).

Download (1MB) | Preview

Psoriasis is the skin disease that most frequently affects the nails. Depending on the very nail structure involved, different clinical nail alterations can be observed. Irritation of the apical matrix results in psoriatic pits, mid-matrix involvement may cause leukonychia, whole matrix affection may lead to red lunulae or severe nail dystrophy, nail bed involvement may cause salmon spots, subungual hyperkeratosis, and splinter hemorrhages, and psoriasis of the distal nail bed and hyponychium causes onycholysis whereas that of the proximal nail fold causes psoriatic paronychia. The more extensive the involvement, the more severe is the nail destruction. Pustular psoriasis may be seen as yellow spots under the nail or, in case of acrodermatitis continua suppurativa, as an insidious progressive loss of the nail organ. Nail psoriasis has a severe impact on quality of life and may interfere with professional and other activities. Management includes patient counseling, avoidance of stress and strain to the nail apparatus, and different types of treatment. Topical therapy may be tried but is rarely sufficiently efficient. Perilesional injections with corticosteroids and methotrexate are often beneficial but may be painful and cannot be applied to many nails. All systemic treatments clearing widespread skin lesions usually also clear the nail lesions. Recently, biologicals were introduced into nail psoriasis treatment and found to be very effective. However, their use is restricted to severe cases due to high cost and potential systemic adverse effects.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Haneke, Eckart

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2230-326X

Publisher:

Dove Medical Press

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

19 Mar 2018 09:38

Last Modified:

19 Mar 2018 09:38

Publisher DOI:

10.2147/PTT.S126281

PubMed ID:

29387608

BORIS DOI:

10.7892/boris.110199

URI:

https://boris.unibe.ch/id/eprint/110199

Actions (login required)

Edit item Edit item
Provide Feedback