Elevated levels of the antimicrobial peptide LL-37 in hidradenitis suppurativa are associated with a Th1/Th17 immune response.

Thomi, Rahel; Schlapbach, Christoph; Yawalkar, Nikhil; Simon, Dagmar; Yerly, Daniel; Hunger, Robert (2018). Elevated levels of the antimicrobial peptide LL-37 in hidradenitis suppurativa are associated with a Th1/Th17 immune response. Experimental dermatology, 27(2), pp. 172-177. Blackwell 10.1111/exd.13482

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Hidradenitis suppurativa (HS) is an inflammatory skin disease with poorly understood immunopathogenic mechanisms. LL-37 is an antimicrobial peptide, which is transcribed from the CAMP (cathelicidin antimicrobial peptide) gene. Previous reports showed upregulated levels of CAMP and LL-37 in HS lesions, and therefore, the aim of this study was to compare levels of LL-37 in HS to other inflammatory skin diseases and to establish immunomodulatory functions of LL-37 in HS. We confirm an upregulation of the LL-37 peptide in lesional HS skin with comparable levels as in psoriasis patients and are able to positively correlate the presence of LL-37 in HS with the presence of T cells, macrophages, neutrophils, IFN-γ, IL-17, IL-23, TNF-α, IL-32 and IL-1β. Mechanistically, LL-37 boosts the proliferation of unspecifically activated CD4+ T cells via an increased calcium signalling independent of antigen-presenting cells. Targeting LL-37 may therefore represent a new therapeutic option for the treatment of this recalcitrant disease, but it has to be kept in mind that LL-37 also has an antimicrobial function.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Schlapbach, Christoph; Yawalkar, Nikhil; Simon, Dagmar; Yerly, Daniel and Hunger, Robert

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0906-6705

Publisher:

Blackwell

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

10 Apr 2018 12:05

Last Modified:

01 Mar 2019 02:30

Publisher DOI:

10.1111/exd.13482

PubMed ID:

29222824

Uncontrolled Keywords:

T-cell proliferation antimicrobial peptide cytokine correlations inflammatory skin disease suggested pro-inflammatory loop

BORIS DOI:

10.7892/boris.110228

URI:

https://boris.unibe.ch/id/eprint/110228

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