Changes in health-related quality of life over a 1-year follow-up period in children with inflammatory bowel disease.

Werner, Helene; Landolt, Markus A; Buehr, Patrick; Koller, Rebekka; Nydegger, Andreas; Spalinger, Johannes; Heyland, Klaas; Schibli, Susanne; Braegger, Christian P (2017). Changes in health-related quality of life over a 1-year follow-up period in children with inflammatory bowel disease. Quality of life research, 26(6), pp. 1617-1626. Springer 10.1007/s11136-017-1513-9

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PURPOSE

Little is known about disease-specific health-related quality-of-life (HRQoL) changes over time in paediatric patients with inflammatory bowel disease (IBD), and about their associations with baseline medical characteristics.

METHODS

In this study, 153 paediatric patients with IBD from the multicentre prospective Swiss IBD cohort study were included at baseline. Of these, 90 patients were analysed at a 1-year follow-up. Medical data were extracted from hospital records, while HRQoL data were measured using the standardized, self-report disease-specific IMPACT-III questionnaire.

RESULTS

The IBD diagnosis of the included children was made an average of 2.0 years before their baseline assessment. Over the 1-year follow-up period, a significant increase in overall HRQoL and in the HRQoL domain 'physical functioning' was evident. On multivariate analysis, overall HRQoL changes over time were predicted by baseline HRQoL, baseline disease activity, and disease activity changes over time. HRQoL improvements were significantly associated with decreases in physician-assessed disease activity. Children reporting a low baseline HRQoL and children with inactive or mildly-active disease experienced greater improvements.

CONCLUSIONS

Children with more severe baseline disease activity had the greatest risk for HRQoL deterioration over the 1-year follow-up period. However, among possible factors that might influence HRQoL changes over time, the child's medical characteristics explained only a small proportion of their variability in our sample. We, therefore, recommend that researchers and clinicians focus on factors that are not incorporated within the multidimensional HRQoL concept if they seek to gain better insights into factors that influence HRQoL changes over time in children with IBD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Spalinger, Johannes, Schibli, Susanne

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0962-9343

Publisher:

Springer

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

20 Feb 2018 15:42

Last Modified:

05 Dec 2022 15:10

Publisher DOI:

10.1007/s11136-017-1513-9

PubMed ID:

28197756

Uncontrolled Keywords:

Children Chronic disease Health-related quality of life Inflammatory bowel disease Paediatric Psychological adaptation

BORIS DOI:

10.7892/boris.110287

URI:

https://boris.unibe.ch/id/eprint/110287

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