Host-microbiota interactions and adaptive immunity.

McCoy, Kathy D; Ronchi, Francesca; Geuking, Markus B (2017). Host-microbiota interactions and adaptive immunity. Immunological reviews, 279(1), pp. 63-69. Wiley-Blackwell 10.1111/imr.12575

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All mucosal surfaces are colonized with a vast number of microbes, which are essential for stimulating and regulating the immune system. While intrinsic and innate mechanisms exist to promote a strong barrier between the microbiota and the host to ensure compartmentalization, the microbiota is also able to induce robust adaptive immunity. In this review, we discuss the interplay between the microbiota and the adaptive immune system, with a focus on the induction of mucosal and systemic antibody responses and newly defined roles of maternal antibodies. We also highlight recent studies that aim to decipher microbial antigen-specificity of the T-cell compartment.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Ronchi, Francesca

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0105-2896

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

01 Feb 2018 09:36

Last Modified:

01 Feb 2018 09:36

Publisher DOI:

10.1111/imr.12575

PubMed ID:

28856735

Uncontrolled Keywords:

B cell lineages and subsets IgA T cell lineages and subsets antibodies microbiota mucosal tissues

BORIS DOI:

10.7892/boris.110304

URI:

https://boris.unibe.ch/id/eprint/110304

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