Circulating fibroblast growth factor 21 in patients with liver cirrhosis.

Krautbauer, Sabrina; Rein-Fischboeck, Lisa; Haberl, Elisabeth M; Pohl, Rebekka; Wiest, Reiner; Buechler, Christa (2018). Circulating fibroblast growth factor 21 in patients with liver cirrhosis. Clinical and experimental medicine, 18(1), pp. 63-69. 10.1007/s10238-017-0468-z

[img] Text
s10238-017-0468-z.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (650kB) | Request a copy

Fibroblast growth factor 21 (FGF21) is an adipokine and hepatokine, and its hepatic expression is induced in the injured liver. Adiponectin, whose systemic levels are positively correlated with measures of hepatic injury in patients with liver cirrhosis, is a downstream effector of FGF21. The aim of the present study was to identify possible associations of serum FGF21 with measures of liver function in patients with liver cirrhosis. FGF21 was determined by ELISA in serum of 42 patients. FGF21 was not linked to disease severity assessed by the Child-Pugh and MELD score. Levels were not changed in those patients with varices and/or ascites. Systemic FGF21 did not correlate with markers of liver and kidney function, inflammatory proteins or adipokines like adiponectin. Levels in hepatic and portal vein of 37 patients were also measured, but there was no transhepatic FGF21 gradient. Three months after insertion of a transjugular intrahepatic shunt hepatic venous pressure gradient was markedly improved, while FGF21 in serum of these 13 patients was not changed. The present study shows that hepatic release and systemic FGF21 are not linked to measures of liver function in patients with liver cirrhosis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Wiest, Reiner

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1591-9528

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

01 Feb 2018 11:57

Last Modified:

08 Feb 2018 01:33

Publisher DOI:

10.1007/s10238-017-0468-z

PubMed ID:

28744589

Uncontrolled Keywords:

Adiponectin Ascites Child–Pugh Portal vein

BORIS DOI:

10.7892/boris.110316

URI:

https://boris.unibe.ch/id/eprint/110316

Actions (login required)

Edit item Edit item
Provide Feedback