Diagnostic Value of Systemic Cholesteryl Ester/Free Cholesterol Ratio in Hepatocellular Carcinoma.

Krautbauer, Sabrina; Weiss, Thomas S; Wiest, Reiner; Schacherer, Doris; Liebisch, Gerhard; Buechler, Christa (2017). Diagnostic Value of Systemic Cholesteryl Ester/Free Cholesterol Ratio in Hepatocellular Carcinoma. Anticancer research, 37(7), pp. 3527-3535. International Inst. of Anticancer Research 10.21873/anticanres.11721

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BACKGROUND

Hepatocellular carcinoma (HCC) most commonly occurs in the setting of liver cirrhosis which is characterized by low serum lipids. We hypothesized that composition of lipoproteins and consequently lipid species ratios are mostly unchanged in patients with cirrhosis compared to controls. This approach may be appropriate to identify lipid ratios altered in HCC irrespective of liver dysfunction.

PATIENTS AND METHODS

Lipids were measured in serum of 21 patients with HCC, 41 patients with liver cirrhosis and 22 controls. Ratios of lipids known to be changed in HCC tissues were calculated.

RESULTS

Ratios of polyunsaturated to mono-unsaturated lysophosphatidylcholine, ceramide/sphingomyelin and cholesteryl ester/free cholesterol were changed in HCC compared to both control cohorts. The latter was most suited to diagnosing HCC. Systemic ratios of these lipid classes were not associated with fibrosis, staging or grade in patients with HCC.

CONCLUSION

The cholesteryl ester/free cholesterol ratio is comparable in controls and patients with cirrhosis, but is specifically increased in patients with HCC.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
UniBE Contributor:	Wiest, Reiner
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0250-7005
Publisher:	International Inst. of Anticancer Research
Language:	English
Submitter:	Thi Thao Anh Pham
Date Deposited:	01 Feb 2018 12:07
Last Modified:	05 Dec 2022 15:10
Publisher DOI:	10.21873/anticanres.11721
PubMed ID:	28668842
Uncontrolled Keywords:	Phospholipids cholesterol hepatocellular carcinoma liver cirrhosis
URI:	https://boris.unibe.ch/id/eprint/110317