Patterns of chronic hand eczema: a semantic map analysis of the CARPE registry data.

Cazzaniga, Simone; Apfelbacher, C; Diepgen, T; Ofenloch, R F; Weisshaar, E; Molin, S; Bauer, A; Mahler, V; Elsner, P; Schmitt, J; Ballmer-Weber, B K; Spring, P; Naldi, L; Borradori, Luca; Simon, Dagmar (2018). Patterns of chronic hand eczema: a semantic map analysis of the CARPE registry data. British journal of dermatology, 178(1), pp. 229-237. Wiley-Blackwell 10.1111/bjd.15660

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BACKGROUND Hand eczema has a high incidence and prevalence and has a negative impact on both physical and psychological well-being, with the risk of persistence as a chronic condition. Epidemiological studies on hand eczema provided mainly descriptive and risk analyses, but pattern analyses of variables associated with hand eczema, in particular chronic hand eczema, have not been explored to date. OBJECTIVES To investigate and display the semantics of associations between variables of hand eczema obtained from the Swiss and German registries of chronic hand eczema (CARPE) to dissect patterns and novel links. METHODS This was a cross-sectional study on selected variables from the CARPE registries. Associations between variables were analysed by means of an autoassociative system. A semantic connectivity map was generated by using a maximum spanning tree algorithm. RESULTS Baseline datasets of 1466 patients with chronic hand eczema (Switzerland: 199; Germany: 1267) were analysed. Occupational exposure had the highest impact in the total and country cohorts. We identified two areas of exposure linked to corresponding occupations that clearly demarcated the sexes. CONCLUSIONS This study, using semantic connectivity as a novel method of data analysis, reveals the complexity of features characterizing chronic hand eczema as well as novel association patterns that deserve further investigation.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Cazzaniga, Simone; Borradori, Luca and Simon, Dagmar


600 Technology > 610 Medicine & health








Sandra Nyffenegger

Date Deposited:

10 Apr 2018 11:47

Last Modified:

29 Oct 2019 18:50

Publisher DOI:


PubMed ID:





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