Current concepts in eosinophilic esophagitis.

Simon, Dagmar; Straumann, Alex; Schoepfer, Alain M; Simon, Hans-Uwe (2017). Current concepts in eosinophilic esophagitis. Allergo journal international, 26(7), pp. 258-266. Springer 10.1007/s40629-017-0037-8

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Background Eosinophilic esophagitis (EoE) is a disease entity first described in the 1990s, but showing an increasing incidence that is characterized clinically by esophageal dysfunction and histologically by a striking eosinophil infiltration. Methods This article discusses new aspects of the pathogenesis, symptoms, diagnosis, and treatment of EoE. Results EoE affects both children and adults and is frequently associated with atopic disease and IgE sensitization. Barrier dysfunction and T‑helper 2 inflammation are considered to be pathogenetically important factors. Recently, a proton pump inhibitor (PPI)-sensitive EoE subtype as well as an EoE-like disorder have been described. Conclusion Research in recent years has contributed to a better understanding of the disease spectrum and pathogenesis of EoE, including genetic dispositions, thereby laying the foundation for innovative treatment approaches.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Simon, Dagmar and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2197-0378

Publisher:

Springer

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

23 Feb 2018 15:33

Last Modified:

23 Feb 2018 15:33

Publisher DOI:

10.1007/s40629-017-0037-8

PubMed ID:

29104849

Uncontrolled Keywords:

Barrier dysfunction Diet Eosinophilic esophagitis Eosinophils T‑helper 2 inflammation

BORIS DOI:

10.7892/boris.110553

URI:

https://boris.unibe.ch/id/eprint/110553

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