Urticaria and Angioedema: an Update on Classification and Pathogenesis.

Radonjic, Susanne Irene; Hofmeier, Kathrin Scherer; Micaletto, Sara; Schmid-Grendelmeier, Peter; Bircher, Andreas; Simon, Dagmar (2018). Urticaria and Angioedema: an Update on Classification and Pathogenesis. Clinical reviews in allergy & immunology, 54(1), pp. 88-101. Humana Press 10.1007/s12016-017-8628-1

[img] Text
10.1007_s12016-017-8628-1.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (746kB) | Request a copy

Urticaria is a common, mast cell-driven disease presenting with wheals or angioedema or both. In the last years, urticaria has increasingly attracted notice to clinicians and researchers, last but not least inspired by the approval of omalizumab, an anti-IgE antibody, for urticaria treatment. There is wide consensus on the clinical classification based on duration and elicitation. However, the pathogenesis is incompletely understood. This review summarizes current guidelines for the management and novel insights in the pathogenesis of urticaria with special focus on their impact on clinical praxis. The classification of urticaria subgroups is mainly based on clinical criteria: acute and chronic urticaria (CU). Chronic urticaria comprises both chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU) that includes physical and non-physical urticarias. Recent research focused on characterizing the role of cells and mediators involved in the pathogenesis of urticaria, identifying the mechanisms of mast cell activation, and investigating underlying autoimmune processes in chronic spontaneous urticarial. Currently, non-sedating antihistamines and omalizumab, an antiimmunoglobulin E antibody, are recommended for the therapy of chronic urticaria, as both exhibit a favorable efficacy and safety profile. Novel therapeutic strategies aim at specifically targeting cells and mediators involved in the pathogenesis of urticaria.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Radonjic, Susanne Irene and Simon, Dagmar


600 Technology > 610 Medicine & health




Humana Press




Andrea Studer-Gauch

Date Deposited:

10 Apr 2018 11:55

Last Modified:

23 May 2022 16:05

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Angioedema Histamine Mast cell Omalizumab Urticaria





Actions (login required)

Edit item Edit item
Provide Feedback