Major findings and recent advances in virus-like particle (VLP)-based vaccines.

Mohsen, Mona; Zha, Lisha; Cabral-Miranda, Gustavo; Bachmann, Martin (2017). Major findings and recent advances in virus-like particle (VLP)-based vaccines. Seminars in immunology, 34, pp. 123-132. W.B. Saunders 10.1016/j.smim.2017.08.014

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Virus-like particles (VLPs) have made giant strides in the field of vaccinology over the last three decades. VLPs constitute versatile tools in vaccine development due to their favourable immunological characteristics such as their size, repetitive surface geometry, ability to induce both innate and adaptive immune responses as well as being safe templates with favourable economics. Several VLP-based vaccines are commercially available including vaccines against Human Papilloma Virus (HPV) such as Cervarix®, Gardasil® & Gardasil9® and Hepatitis B Virus (HBV) including the 3rd generation Sci-B-Vac™. In addition, the first licensed malaria-VLP-based vaccine Mosquirix™ has been recently approved by the European regulators. Several other VLP-based vaccines are currently undergoing preclinical and clinical development. This review summarizes some of the major findings and recent advances in VLP-based vaccine development and technologies and outlines general principles that may be harnessed for induction of targeted immune responses.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie

UniBE Contributor:

Mohsen, Mona; Zha, Lisha and Bachmann, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1044-5323

Publisher:

W.B. Saunders

Language:

English

Submitter:

Eveline Messerli

Date Deposited:

19 Mar 2018 13:58

Last Modified:

24 Oct 2019 09:06

Publisher DOI:

10.1016/j.smim.2017.08.014

PubMed ID:

28887001

Uncontrolled Keywords:

Innate & adaptive immune response Vaccine Virus Virus-like particles

BORIS DOI:

10.7892/boris.110609

URI:

https://boris.unibe.ch/id/eprint/110609

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