Leucopenia associated with metamizole: a case-control study.

Blaser, Lea; Hassna, Hala; Hofmann, Sarah; Holbro, Andreas; Haschke, Manuel Martin; Rätz Bravo, Alexandra; Zeller, Andreas; Krähenbühl, Stephan; Taegtmeyer, Anne (2017). Leucopenia associated with metamizole: a case-control study. Swiss medical weekly, 147, w14438. EMH Schweizerischer Ärzteverlag 10.4414/smw.2017.14438

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AIMS OF THE STUDY

The aim of this study was to identify possible risk factors for the development of leucopenia associated with metamizole use.

METHODS

A retrospective case-control study was performed. Cases of metamizole-associated leucopenia managed at a single centre (2005-2013) were characterised and compared with matched controls who took metamizole without developing complications.

RESULTS

Fifty-seven cases and 139 controls were identified. Of the cases, 32 were postoperative and these were compared to age-, sex- and ward-matched postoperative controls (n = 64). The remaining cases (n = 25) were compared to sex-matched, non-postoperative controls (n = 75). The number of patients with a positive allergy history was higher among postoperative cases than controls (p = 0.004) as was the number with previous leucopenic episodes (p = 0.03). The prevalence of diagnosed hepatitis C infection was 9% among all cases compared with 1% among all controls (p = 0.005). The use of concomitant cytostatic agents (even at immunosuppressive doses) was significantly higher among non-postoperative cases than controls (p = 0.011). There was no association between renal function and the development of leucopenia.

CONCLUSIONS

A history of allergies, previous leucopenic episodes, hepatitis C infection and concomitant cytostatic agents are possible risk factors for leucopenia associated with metamizole use.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Haschke, Manuel Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Jacques Donzé

Date Deposited:

07 Mar 2018 14:53

Last Modified:

25 Oct 2019 19:12

Publisher DOI:

10.4414/smw.2017.14438

PubMed ID:

28634963

BORIS DOI:

10.7892/boris.110661

URI:

https://boris.unibe.ch/id/eprint/110661

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