Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus.

Spindler, Volker; Eming, Rüdiger; Schmidt, Enno; Amagai, Masayuki; Grando, Sergei; Jonkman, Marcel F; Kowalczyk, Andrew P; Müller, Eliane Jasmine; Payne, Aimee S; Pincelli, Carlo; Sinha, Animesh A; Sprecher, Eli; Zillikens, Detlef; Hertl, Michael; Waschke, Jens (2018). Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus. Journal of Investigative Dermatology, 138(1), pp. 32-37. Nature Publishing 10.1016/j.jid.2017.06.022

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The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Müller, Eliane Jasmine

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

0022-202X

Publisher:

Nature Publishing

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

16 Apr 2018 09:38

Last Modified:

16 Apr 2018 09:38

Publisher DOI:

10.1016/j.jid.2017.06.022

PubMed ID:

29037765

BORIS DOI:

10.7892/boris.110730

URI:

https://boris.unibe.ch/id/eprint/110730

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