Biology and evolution of poorly differentiated neuroendocrine tumors.

Rickman, David S; Beltran, Himisha; Demichelis, Francesca; Rubin, Mark Andrew (2017). Biology and evolution of poorly differentiated neuroendocrine tumors. Nature medicine, 23(6), pp. 664-673. Nature Publishing Group 10.1038/nm.4341

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Neuroendocrine (NE) cancers are a diverse group of neoplasms typically diagnosed and treated on the basis of their site of origin. This Perspective focuses on advances in our understanding of the tumorigenesis and treatment of poorly differentiated neuroendocrine tumors. Recent evidence from sequencing indicates that, although neuroendocrine tumors can arise de novo, they can also develop as a result of lineage plasticity in response to pressure from targeted therapies. We discuss the shared genomic alterations of these tumors independently of their site of origin, and we explore potential therapeutic strategies on the basis of recent biological findings.

Item Type:

Journal Article (Further Contribution)

UniBE Contributor:

Rubin, Mark Andrew

Subjects:

500 Science
500 Science > 570 Life sciences; biology

ISSN:

1078-8956

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Marla Rittiner

Date Deposited:

02 Feb 2018 12:15

Last Modified:

04 Nov 2019 11:49

Publisher DOI:

10.1038/nm.4341

PubMed ID:

28586335

BORIS DOI:

10.7892/boris.110781

URI:

https://boris.unibe.ch/id/eprint/110781

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