Importance of Timing First-Trimester Placental Growth Factor and Use of Serial First-Trimester Placental Growth Factor Measurements in Screening for Preeclampsia.

Mosimann, Beatrice; Amylidi-Mohr, Sofia; Höland, Katrin; Surbek, Daniel; Risch, Lorenz; Raio, Luigi (2017). Importance of Timing First-Trimester Placental Growth Factor and Use of Serial First-Trimester Placental Growth Factor Measurements in Screening for Preeclampsia. Fetal diagnosis and therapy, 42(2), pp. 111-116. Karger 10.1159/000455946

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OBJECTIVE The aims of this study were to test whether the performance of first-trimester placental growth factor (PlGF) in screening for preterm preeclampsia (PE) is gestational age dependent and to assess the value of serial first-trimester PlGF measurements in discriminating women at risk for PE. METHODS PlGF was measured in women with singleton pregnancies at their first antenatal visit at 8+0 to 10+6 and additionally at 11+0 to 14+0 weeks of gestation. The difference in absolute values of serial PlGF measurements was expressed as Δ-PlGF. Values were compared between pregnancies with normal outcome and those complicated by PE. RESULTS A total of 814 pregnancies were included, 18 (2.19%) developed PE that required delivery before 37 weeks of gestation. PlGF increases significantly from 8 to 14 weeks of gestation (ρ = 0.63; p < 0.0001) in normal pregnancies, but not so in preterm PE (ρ = 0.034; p = 0.893). PlGF discriminates between PE and uneventful pregnancies only after 10 weeks of gestation. Δ-PlGF was significantly lower in PE 5.3 (-1.1 to 9.3) pg/mL compared to uneventful pregnancies 17.3 (9.8-26.0) pg/mL (p = 0.0011). CONCLUSION The discriminatory accuracy of PlGF increases from 10 to 14 weeks of gestation, and serial PlGF measurements might be of particular interest in PE screening.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Mosimann, Beatrice; Amylidi, Sofia Kalypso; Surbek, Daniel; Risch, Lorenz and Raio, Luigi

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1015-3837

Publisher:

Karger

Language:

English

Submitter:

Monika Zehr

Date Deposited:

02 Feb 2018 13:30

Last Modified:

24 Oct 2019 20:41

Publisher DOI:

10.1159/000455946

PubMed ID:

28199996

Uncontrolled Keywords:

First trimester Placental growth factor Preeclampsia Prenatal screening

BORIS DOI:

10.7892/boris.110783

URI:

https://boris.unibe.ch/id/eprint/110783

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