Mosimann, Beatrice; Amylidi-Mohr, Sofia; Höland, Katrin; Surbek, Daniel; Risch, Lorenz; Raio, Luigi (2017). Importance of Timing First-Trimester Placental Growth Factor and Use of Serial First-Trimester Placental Growth Factor Measurements in Screening for Preeclampsia. Fetal diagnosis and therapy, 42(2), pp. 111-116. Karger 10.1159/000455946
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OBJECTIVE
The aims of this study were to test whether the performance of first-trimester placental growth factor (PlGF) in screening for preterm preeclampsia (PE) is gestational age dependent and to assess the value of serial first-trimester PlGF measurements in discriminating women at risk for PE.
METHODS
PlGF was measured in women with singleton pregnancies at their first antenatal visit at 8+0 to 10+6 and additionally at 11+0 to 14+0 weeks of gestation. The difference in absolute values of serial PlGF measurements was expressed as Δ-PlGF. Values were compared between pregnancies with normal outcome and those complicated by PE.
RESULTS
A total of 814 pregnancies were included, 18 (2.19%) developed PE that required delivery before 37 weeks of gestation. PlGF increases significantly from 8 to 14 weeks of gestation (ρ = 0.63; p < 0.0001) in normal pregnancies, but not so in preterm PE (ρ = 0.034; p = 0.893). PlGF discriminates between PE and uneventful pregnancies only after 10 weeks of gestation. Δ-PlGF was significantly lower in PE 5.3 (-1.1 to 9.3) pg/mL compared to uneventful pregnancies 17.3 (9.8-26.0) pg/mL (p = 0.0011).
CONCLUSION
The discriminatory accuracy of PlGF increases from 10 to 14 weeks of gestation, and serial PlGF measurements might be of particular interest in PE screening.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry |
UniBE Contributor: |
Mosimann, Beatrice, Amylidi-Mohr, Sofia, Surbek, Daniel, Risch, Lorenz, Raio, Luigi |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1015-3837 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Monika Zehr |
Date Deposited: |
02 Feb 2018 13:30 |
Last Modified: |
02 Mar 2023 23:30 |
Publisher DOI: |
10.1159/000455946 |
PubMed ID: |
28199996 |
Uncontrolled Keywords: |
First trimester Placental growth factor Preeclampsia Prenatal screening |
BORIS DOI: |
10.7892/boris.110783 |
URI: |
https://boris.unibe.ch/id/eprint/110783 |
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