Rubin, Mark Andrew; Demichelis, Francesca (2018). The Genomics of Prostate Cancer: emerging understanding with technologic advances. Modern pathology, 31(S1), S1-11. Nature Publishing Group 10.1038/modpathol.2017.166
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With the advent of next-generation sequencing technologies and large whole-exome and genome studies in prostate and other cancers, our understanding of the landscape of genomic alterations has dramatically been refined. In additional to well-known alterations in genomic regions involving 8p, 8q, 10q23, common ETS translocations and androgen receptor amplifications, newer technology have uncovered recurrent mutations in SPOP, FOXA1, MED12, IDH and complex large scale genomic alterations (eg, chromoplexy). This review surveys the enhanced landscape of genomic alterations in clinically localized and advanced prostate cancer.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie |
UniBE Contributor: |
Rubin, Mark Andrew |
Subjects: |
500 Science 500 Science > 570 Life sciences; biology |
ISSN: |
0893-3952 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Marla Rittiner |
Date Deposited: |
08 Mar 2018 15:16 |
Last Modified: |
05 Dec 2022 15:10 |
Publisher DOI: |
10.1038/modpathol.2017.166 |
PubMed ID: |
29297493 |
BORIS DOI: |
10.7892/boris.110878 |
URI: |
https://boris.unibe.ch/id/eprint/110878 |
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