Bulkamid (PAHG) in mixed urinary incontinence: What is the outcome?

Mohr, Stefan; Marthaler-Benender, Christine; Imboden, Sara; Monga, Ash; Mueller, Michael; Kuhn, Annette (2017). Bulkamid (PAHG) in mixed urinary incontinence: What is the outcome? International urogynecology journal, 28(11), pp. 1657-1661. Springer 10.1007/s00192-017-3332-5

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INTRODUCTION AND HYPOTHESIS Mixed urinary incontinence (MUI), defined as mixed symptoms of stress urinary incontinence (SUI) and overactive bladder (OAB), is a difficult entity if conservative treatment has failed. Cure rates are low compared with SUI, particularly the OAB component, may deteriorate after sling insertion. Bulking agents pose an appealing alternative for the treatment of MUI. They have shown beneficial effect in small case studies, but larger series are lacking. The aim of this prospective study was an analysis of treatment efficacy and safety profile of the bulking agent, Bulkamid, in female patients with MUI. METHODS One hundred fifty-four women with MUI symptoms (components of SUI/OAB within the limits of 60-40% either way) received bulking therapy with polyacrylamide hydrogel (Bulkamid). Patients were followed-up 3 months postoperatively. Primary outcome was the domain Incontinence impact on the King's Health Questionnaire (KHQ). Secondary outcomes were the other KHQ domains, visual analog scale (VAS), and International Continence Society (ICS) standardized pad weight test as objective measurement of incontinence. RESULTS Statistically significant improvements were found for all KHQ domains, pad weight test, and the visual analog scale (VAS) before and after bulking. Overall complication rate was 13%. CONCLUSIONS This study has shown improvement in MUI after bulking therapy according to both subjective and objective outcomes. We can advocate bulking therapy for treating MUI, as it is simple and safe and shows both objective and subjective improvement and relief. Long-term results (up to 1 year) are awaited.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Mohr, Stefan; Marthaler-Benender, Christine; Imboden, Sara; Mueller, Michael and Kuhn, Annette


600 Technology > 610 Medicine & health








Monika Zehr

Date Deposited:

20 Mar 2018 12:25

Last Modified:

23 Oct 2019 14:37

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Bulking agent Bulking therapy Mixed urinary incontinence Overactive bladder Periurethral bulking Stress urinary incontinence





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